Anti-PTPRT antibody produced in rabbit

PTPRT (protein tyrosine phosphatase, receptor type, T) is a type II receptor protein tyrosine phosphatase belonging to the RPTPμ/κ phosphatase subfamily. It consists of a MAM (meprin/A5-protein/PTPmu) domain near the N-terminal, an immunoglobulin-like domain, four fibronectin type III repeats, a single transmembrane domain, and a large juxtamembrane segment and two phosphatase domains at the intracellular end. In humans, it is located to the chromosome 20 and expressed in the central nervous system (CNS) specifically in the brain and spinal cord.

Receptor-type tyrosine-protein phosphatase T precursor recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

PTPRT (protein tyrosine phosphatase, receptor type, T) presence in CNS (central nervous system) may prove its functional importance in both signal transduction and cellular adhesion. Somatic mutations in PTPRT gene cause colorectal cancers. It has been reported that mutated PTPRT influences tyrosine phosphorylation, which further reduces phosphatase activity.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST72491

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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