产品名称
抗-S100B 兔抗, affinity isolated antibody, buffered aqueous glycerol solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
human
enhanced validation
recombinant expression
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
technique(s)
immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:1000-1:2500
immunogen sequence
LEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE
UniProt accession no.
application(s)
research pathology
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... S100B(6285)
Application
Biochem/physiol Actions
S-100 β亚基（S100B）对神经元和神经胶质具有旁分泌和自分泌作用。在纳摩尔浓度下，编码的蛋白质在发育过程中可促进神经突起的生长、增加神经元的存活率。S100B是黑素细胞细胞毒性的标志物。另外，它还可以作为内分泌抵抗型乳腺癌和非节段型白癜风的血清标志物。在慢性肝病患者体内，观察到S100B的表达降低。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
Prestige Antibodies®是经过高度表征和广泛验证的抗体，同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige Antibodies®对其他蛋白质的独特性和低交叉反应性是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。每种Prestige 抗体都有相应的Prestige 抗原对照品，可在链接部分找到。
每种Prestige 抗体的检测方法如下：
每种Prestige 抗体的检测方法如下：
- 44种正常人体组织和20种最常见癌症组织的IHC组织阵列。
- 364个人重组蛋白片段的蛋白阵列。
General description
S100B是一种Ca2+结合蛋白，由星形胶质细胞通过自分泌途径分泌，以激活一氧化氮的释放。S100B可能调节小胶质细胞的功能。它也可能与神经胶质细胞中中间丝和微管的动力学有关。抗S100B抗体对人的S100B具有特异性。编码S100B的基因位于人染色体21上。
Immunogen
蛋白S-100重组蛋白表位信号标签（PrEST）
Other Notes
对应抗原APREST73328
Physical form
磷酸盐缓冲盐水溶液，pH 7.2，含有40%甘油和0.02%叠氮化钠
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Association of S100B with intermediate filaments and microtubules in glial cells
Sorci, G., et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1448(2), 277-289 (1998)
Fei Yang et al.
Life (Basel, Switzerland), 11(6) (2021-07-03)
The role of Langerhans cells (LCs) in vitiligo pathogenesis remains unclear, with published studies reporting contradictory results regarding the quantity of LCs and no data on the features of LCs in vitiligo. Here, we aimed to analyze the presence, density
Elma Aflaki et al.
Neurobiology of disease, 134, 104647-104647 (2019-11-02)
While astrocytes, the most abundant cells found in the brain, have many diverse functions, their role in the lysosomal storage disorder Gaucher disease (GD) has not been explored. GD, resulting from the inherited deficiency of the enzyme glucocerebrosidase and subsequent
Siobhan S Pattwell et al.
Nature communications, 7, 11475-11475 (2016-05-25)
Fear can be highly adaptive in promoting survival, yet it can also be detrimental when it persists long after a threat has passed. Flexibility of the fear response may be most advantageous during adolescence when animals are prone to explore
Lifan Zhu et al.
Molecular medicine reports, 18(6), 4855-4864 (2018-10-04)
The present study aimed to investigate the role of S100B in the inflammation process during osteoarthritis (OA). OA cartilage samples were collected for S100B expression analysis. S100B expression levels were significantly increased in patients with OA compared with the Controls
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