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Merck
CN
所有图片(5)

主要文件

安全信息

HPA015498

Sigma-Aldrich

Anti-GDF10 antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

别名:

Anti-BIP, Anti-BMP-3b, Anti-Bone Morphogenetic Protein 3b precursor, Anti-Bone-inducing protein, Anti-GDF-10, Anti-Growth/differentiation factor 10

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About This Item

UNSPSC代码:
12352203
人类蛋白质图谱编号:
NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

产品线

Prestige Antibodies® Powered by Atlas Antibodies

表单

buffered aqueous glycerol solution

种属反应性

human

技术

immunohistochemistry: 1:20- 1:50

免疫原序列

ISEPNSVAVTLQRYDPFPAGDPEPRAAPNNSADPRVRRAAQATGPLQDNELPGLDERPPRAHAQHFHKHQLWPSPFRALKPRPGRKDRRKKGQEVFMAASQVLDFDEKTMQKA

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... GDF10(2662)

一般描述

GDF10 (growth differentiation factor 10) belongs to the family of bone-morphogenetic protein (BMP) family, which in turn belongs to transforming growth factor β (TGFβ) family. BMP is divided into three groups, where GDF10, also called BMP3B, is a member of the third group. This gene maps to human chromosome 10q, contains 3 exons, spans 13kb and the cDNA has 2632bp, which codes for a protein composed of 478 amino acids. N-terminal signal sequence cleavage yields a mature protein composed of 110 amino acids. The transcript is expressed predominantly in brain, lung, femur, pancreas, testis and skeletal muscle.

免疫原

Bone morphogenetic protein 3b precursor recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

生化/生理作用

GDF10 (growth differentiation factor 10) is epigenetically silenced in multiple cancers such as, colorectal neoplasms and non-small cell lung cancers (NSCLCs). Studies in Japanese population show that this gene is silenced by methylation in malignant pleural mesotheliomas (MPMs). It acts as a tumor suppressor gene in various malignant tumors. It might play a role in the differentiation of various cell types, and might be associated with morphogenesis of skeletal tissues. This gene is regulated by SOX9 and hypoxia-inducible factor.

特点和优势

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST72574

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Kentaro Kimura et al.
Oncology reports, 20(5), 1265-1268 (2008-10-25)
Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-beta superfamily. Recent studies have showed that aberrant methylation of BMP genes is present in several types of human cancer. We examined the expression and methylation status of BMP3b and BMP6
Jérôme E Lafont et al.
The Journal of biological chemistry, 283(8), 4778-4786 (2007-12-14)
The chondrocyte is solely responsible for synthesis and maintenance of the resilient articular cartilage matrix that gives this load-bearing tissue its mechanical integrity. When the differentiated cell phenotype is lost, the matrix becomes compromised and cartilage function begins to fail.
J Hino et al.
Biochemical and biophysical research communications, 223(2), 304-310 (1996-06-14)
BMP-3b (also termed GDF-10) is a novel BMP-3 related protein recently discovered in rat femur tissue by molecular cloning. In this paper, we have isolated cDNA and the gene for human BMP-3b and determined their structure. Cloned human BMP-3b cDNA
N S Cunningham et al.
Growth factors (Chur, Switzerland), 12(2), 99-109 (1995-01-01)
We have identified a new member of the transforming growth factor-beta (TGF-beta) superfamily, growth/differentiation factor-10 (GDF-10), which is highly related to bone morphogenetic protein-3 (BMP-3). The nucleotide sequence of GDF-10 encodes a predicted protein of 476 amino acids with a
Valentina Cerrato et al.
PLoS biology, 16(9), e2005513-e2005513 (2018-09-28)
The morphological, molecular, and functional heterogeneity of astrocytes is under intense scrutiny, but how this diversity is ontogenetically achieved remains largely unknown. Here, by quantitative in vivo clonal analyses and proliferation studies, we demonstrate that the major cerebellar astrocyte types

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