推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
产品线
Prestige Antibodies® Powered by Atlas Antibodies
形式
buffered aqueous glycerol solution
种属反应性
human
增强验证
recombinant expression
Learn more about Antibody Enhanced Validation
技术
immunohistochemistry: 1:50-1:200
western blot: 0.04-0.4 μg/mL
免疫原序列
MEVLESGEQGVLQWDRKLSELSEPGDGEALMYHTHFSELLDEFSQNVLGQLLNDPFLSEKSVSMEVEPSPTSPAPLIQAEHSYSLCEEPRAQSPFTHITTSDSFND
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CREB3L2(64764)
一般描述
CREB3L2 (cAMP responsive element binding protein 3-like 2) is also called BBF2 human homolog on chromosome 7 (BBF2H7), and along with old astrocyte specifically induced substance (OASIS) is a member of the cAMP response element-binding protein (CREB)/ATF (Activating transcription factor) family. It is a transmembrane protein, and acts as a bZIP (basic leucine zipper) transcription factor. This gene has 12 exons, and covers >120kbp. It has a transactivation region in its N-terminal, a leucine zipper, a DNA-binding domain, a transmembrane α-helical hydrophobic region, and a luminal domain. It is an endoplasmic reticulum (ER) protein, but an alternatively spliced variant is found in both ER and nucleus.
免疫原
cAMP-responsive element-binding protein 3-like protein 2 recombinant protein epitope signature tag (PrEST)
应用
Anti-CREB3L2 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
生化/生理作用
CREB3L2 (cAMP responsive element binding protein 3-like 2) confers protection during endoplasmic reticulum (ER) stress, and in response to ER stress is cleaved in its transmembrane region. It regulates the transcription of Sec23A, when it acts like a bZIP transcription factor. This is essential for collagen synthesis in dermal fibroblasts, where it ensures the proper trafficking of procollagen from ER-to-Golgi. It is a fusion partner of FUS gene in low-grade fibromyxoid sarcoma (LGFMS), and this fusion forms a supernumerary ring chromosome, which is related to tumor progression. It is a substrate for F-box and WD repeat domain-containing-7 (Fbxw7) protein, and is degraded by the same. This process, in turn, regulates osteogenesis and chondrogenesis. It also acts as a fusion partner of PPAR (Peroxisome proliferator-activated receptor) γ in thyroid carcinoma, and this fusion inactivates a thyroid signaling pathway.
特点和优势
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
联系
Corresponding Antigen APREST73339
外形
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
法律信息
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
Cancer genetics and cytogenetics, 199(2), 143-146 (2010-05-18)
Low-grade fibromyxoid sarcoma (LGFMS) is a rare, low-grade malignant soft tissue tumor that is often mistaken for either benign or more malignant tumor types. Commonly, this tumor affects young adults and typically arises in the deep proximal extremities or trunk
Clinical cancer research : an official journal of the American Association for Cancer Research, 17(9), 2646-2656 (2011-05-04)
Low-grade fibromyxoid sarcoma (LGFMS) is typically characterized by the specific translocation t(7;16)(q33;p11) and the corresponding fusion gene FUS-CREB3L2. The present study aimed to extract LGFMS-specific, and putatively FUS-CREB3L2-dependent, gene expression patterns to learn more about the pathogenesis of this tumor.
The Journal of biological chemistry, 288(40), 28488-28502 (2013-08-21)
Although identification of substrates for an enzyme is a key step in elucidation of its biological functions, detection of the interaction between enzymes and substrates remains challenging. We recently developed a new approach, termed differential proteomics-based identification of ubiquitylation substrates
Oncology reports, 24(5), 1133-1139 (2010-09-30)
CREB3L2, a member of the CREB3 family of transcription factors, spans >120 kbp and is composed of 12 exons. We characterized a widely expressed transcript of CREB3L2 generated by an intronic polyadenylation site in intron 4 of the gene. It
Cancer research, 68(17), 7156-7164 (2008-09-02)
The discovery of gene fusion mutations, particularly in leukemia, has consistently identified new cancer pathways and led to molecular diagnostic assays and molecular-targeted chemotherapies for cancer patients. Here, we report our discovery of a novel CREB3L2-PPARgamma fusion mutation in thyroid
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门