Anti-FABP6 antibody produced in rabbit

Fatty acid binding protein 6 (FABP6) is localized in the cytosol of cells in the intestine extending from the jejunum to the ascending colon. It is a 15kDa protein belonging to the fatty acid-binding protein family (FABP family).

Gastrotropin recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Fatty acid binding protein 6 (FABP6) is involved in binding and transporting bile acids. It is a part of the farnesoid X receptor (FXR) transcription pathway which responds to bile acids and regulates their reabsorption across the ileum. It also enhances the transcriptional activity of FXR. Bile acids that are secreted in the small intestine are reabsorbed in the ileum. They activate the nuclear FXR and this in turn stimulates the expression of FABP6. The interaction between FXR and FABP6 causes a local increase in bile acid concentration around the ligand-binding domain (LBD) of FXR. This aids the delivery of ligands to the LBD.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST71278

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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