HPA010928
Anti-SFTPC Antibody
Prestige Antibodies® Powered by Atlas Antibodies, rabbit polyclonal
别名:
抗-BRICD6, 抗-PSP-C, 抗-SFTP2, 抗-SMDP2, 抗-SP-C
产品名称
抗-SFTPC 兔抗, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
enhanced validation
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
technique(s)
immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:2500-1:5000
immunogen sequence
PEAQQRLALSEHLVTTATFSIGSTGLVVYDYQQLLIAYKPAPGTCCYIMKIAPESIPSLEALTRKVHNFQAKPAVPTSKLGQAEGRDAGSAPSGGDPAFLGMAVSTLCG
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SFTPC(6440)
Application
兔抗SFTPC抗体可用于免疫组化（IHC）和免疫荧光（IF）分析。
Biochem/physiol Actions
SFTPC（表面活性蛋白C）可稳定肺表面活性剂膜，帮助磷脂吸附在表面活性剂单层上。通过这种方式，它调节构成肺表面活性剂的磷脂的代谢和动力。该基因的突变与婴儿的间质性肺疾病（ILD）有关。SFTPC中的突变可导致各种疾病，例如婴儿的慢性肺部炎症以及成人的普通或脱屑性间质性肺炎和特发性肺纤维化。SFTPC前蛋白的BRICHOS域中的G100S突变导致内质网（ER）应激和细胞凋亡增加。因此，该基因中的G100S突变参与了日本人群家族性肺纤维化的发病机制。SFTPC基因的突变也会导致混合性肺纤维化和肺气肿（CPFE）综合征，其特征是肺气肿，炎症和纤维化。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
Prestige Antibodies®是经过高度表征和广泛验证的抗体，同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige Antibodies®对其他蛋白质的独特性和低交叉反应性是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。每种Prestige 抗体都有相应的Prestige 抗原对照品，可在链接部分找到。
每种Prestige 抗体的检测方法如下：
每种Prestige 抗体的检测方法如下：
- 44种正常人体组织和20种最常见癌症组织的IHC组织阵列。
- 364个人重组蛋白片段的蛋白阵列。
General description
肺表面活性物质是磷脂和蛋白的混合物，具有表面活性，由II型上皮细胞分泌进入肺泡腔。表面活性剂中存在四种蛋白质，即SP（表面活性剂蛋白）-A，SP-B，SP-C或SFTPC和SP-D。SFTPC是一种疏水性蛋白，作为前蛋白产生，并经过翻译后修饰以去除其NH2和COOH前肽。成熟的活性蛋白分子量为3.7 kDa。前蛋白由197个氨基酸组成，仅由2型肺泡（AT2）细胞产生。SFTPC包含BRICHOS域，建议使用该域来防止肽的聚集并调节SFTPC前蛋白的蛋白水解过程。该基因位于人染色体8p21。
Immunogen
肺表面活性剂相关蛋白C前体重组蛋白表位标签（PrEST）
Other Notes
相应抗原APREST72206
Physical form
磷酸盐缓冲盐水溶液，pH 7.2，含有40%甘油和0.02%叠氮化钠
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
常规特殊物品
此项目有
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Analysis of molecular genetic markers in biological fluids has been proposed as a powerful tool for cancer diagnosis. We have characterized in detail the genetic signatures in primary non-small cell lung cancer, which provided potential diagnostic biomarkers for lung cancer.
Recombinant BRICHOS chaperone domains delivered to mouse brain parenchyma by focused ultrasound and microbubbles are internalized by hippocampal and cortical neurons
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Molecular and Cellular Neurosciences, 103498-103498 (2020)
Christoph H Mayr et al.
EMBO molecular medicine, 13(4), e12871-e12871 (2021-03-03)
The correspondence of cell state changes in diseased organs to peripheral protein signatures is currently unknown. Here, we generated and integrated single-cell transcriptomic and proteomic data from multiple large pulmonary fibrosis patient cohorts. Integration of 233,638 single-cell transcriptomes (n = 61) across
Variable phenotype associated with SP-C gene mutations: fatal case with the I73T mutation.
S Percopo et al.
The European respiratory journal, 24(6), 1072-1073 (2004-12-02)
Paul A Stevens et al.
Pediatric research, 57(1), 89-98 (2004-11-24)
Human surfactant protein C (hSP-C(1-197)) is synthesized as a 197 amino acid proprotein and cleaved to a mature 3.7 kD form. Although interstitial lung disease in patients with mutations of the hSP-C gene is becoming increasingly recognized, the mechanisms linking
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