Anti-ANGPTL1 antibody produced in rabbit

ANGPTL1 (angiopoietin like 1), also called angiopoietin-3 (ANG3) is a member of the ANG family. It is composed of 491 amino acids, and is composed of the characteristic conserved coiled-coil domain and fibrinogen-like domain found in ANG family members, in its N- and C-terminals. It also contains the highly hydrophobic leader peptide in its N-terminal. It is a secretory protein and its mRNA is predominant in thyroid, heart, adrenal, placenta and small intestine in adult human tissues. It is also highly expressed in brain.

Angiopoietin-related protein 1 precursor recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

ANGPTL1 (angiopoietin like 1) is a potent angiogenesis regulator. Its expression is negatively related with lymph node metastasis, invasion and poor prognosis. It acts as a tumor suppressor in breast and lung cancer cells. It suppresses SLUG (Snail homolog)-dependent EMT (epithelial mesenchymal transition) in lung cancer, thus, preventing cell motility. It is also thought to function as a transcription repressor. It forms heterodimers with Ear2 (V-erbA-related protein 2), and they may constitute a distinct orphan receptor signaling. It also functions as an agonist of Tie2, which is an endothelial receptor tyrosine kinase.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST86560

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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