HPA009040
Anti-PRRG4 antibody produced in rabbit
affinity isolated antibody, buffered aqueous glycerol solution
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所有图片(1)
Anti-Proline-rich γ-carboxyglutamic acid protein 4 antibody produced in rabbit, Anti-Proline-rich Gla protein 4 antibody produced in rabbit, Anti-Transmembrane γ-carboxyglutamic acid protein 4 precursor antibody produced in rabbit
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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous glycerol solution
种属反应性
human
技术
immunohistochemistry: 1:200-1:500
免疫原序列
NRLQHPCSSAVYERGRHTPSIIFRRPEEAALSPLPPSVEDAGLPSYEQAVALTRKHSVSPPPPYPGHTKGFRVFKKSMSLPSH
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... PRRG4(79056)
一般描述
PRRG4 (proline rich γ-carboxyglutamic acid 4) is a plasma membrane protein, which is composed of putative WW and SH3 binding motifs in its cytoplasmic domain. It contains a transmembrane domain and a Gla domain, a pro peptide and a signal peptide in its extracellular region. It is a ubiquitously expressed protein, with the highest expression in kidney, breast, lung, thyroid and the lowest expression in jejunum, proximal colon, duodenum and uterus. This gene localizes to human chromosome 11.
免疫原
Transmembrane γ-carboxyglutamic acid protein 4 precursor recombinant protein epitope signature tag (PrEST)
应用
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
生化/生理作用
PRRG4 (proline rich γ-carboxyglutamic acid 4) gene is deleted in pateints with WAGR (Wilms tumor, Aniridia, genitourinary malformations, and mental retardation) syndrome. Studies in BALB/c mice, show that this gene is one of the most highly expressed genes in mesenteric lymph node in response to three common food allergens. Genome wide association studies (GWAS) show that SNP (single nucleotide polymorphism) for Parkinson′s disease (PD) with the lowest p-value lies in PRRG4 gene region.
特点和优势
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
联系
Corresponding Antigen APREST71969
外形
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
法律信息
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Cancer cell international, 23(1), 323-323 (2023-12-16)
Breast cancer is the leading cause of cancer death for women worldwide. Most of the breast cancer death are due to disease recurrence and metastasis. Increasingly accumulating evidence indicates that mitochondria play key roles in cancer progression and metastasis. Our
BMC medical genetics, 10, 98-98 (2009-09-24)
Age at onset in Parkinson disease (PD) is a highly heritable quantitative trait for which a significant genetic influence is supported by multiple segregation analyses. Because genes associated with onset age may represent invaluable therapeutic targets to delay the disease
The Journal of biological chemistry, 288(36), 25908-25914 (2013-07-23)
The genes encoding a family of proteins termed proline-rich γ-carboxyglutamic acid (PRRG) proteins were identified and characterized more than a decade ago, but their functions remain unknown. These novel membrane proteins have an extracellular γ-carboxyglutamic acid (Gla) protein domain and
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