HPA009026
Anti-RRBP1 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
登录查看公司和协议定价
所有图片(11)
Anti-180 kDa ribosome receptor homolog antibody produced in rabbit, Anti-ES/130-related protein antibody produced in rabbit, Anti-Ribosome receptor protein antibody produced in rabbit, Anti-Ribosome-binding protein 1 antibody produced in rabbit
推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
产品线
Prestige Antibodies® Powered by Atlas Antibodies
形式
buffered aqueous glycerol solution
种属反应性
human
增强验证
orthogonal RNAseq
independent
Learn more about Antibody Enhanced Validation
技术
immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:2500-1:5000
免疫原序列
ELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREK
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... RRBP1(6238)
正在寻找类似产品? 访问 产品对比指南
相关类别
一般描述
RRBP1 (ribosome binding protein 1) is a membrane protein that localizes to endoplasmic reticulum (ER). It is also found in cytoplasm and nucleus. This protein is composed of 1410 amino acids, a transmembrane domain in its hydrophobic N-terminal, a highly conserved tandem repeat which functions as the ribosome-binding domain, and the C-terminal which contains an acidic coiled-coil domain.
免疫原
Ribosome-binding protein 1 recombinant protein epitope signature tag (PrEST)
应用
Anti-RRBP1 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
生化/生理作用
RRBP1 (ribosome binding protein 1) is a key ribosome binding protein and plays essential role in the translocation of naïve proteins across the membrane of endoplasmic reticulum (ER). It is essential for the terminal differentiation of secretory tissues, and for the production of pro-collagen in secretory tissues. It also functions as the interacting partner of the motor protein KIF5B (kinesin family member 5B), which is up-regulated in several cancer cell lines. RRBP1 protein is highly expressed in breast cancer (BC) cells and might have potential as a BC marker. This protein is essential for the ER-localization of bulk poly(A) and of certain mRNAs such as, placental alkaline phosphatase and calreticulin. Up-regulation of this protein promotes the progression of colorectal cancer, and functions as a predictor of poor outcome in post-operative cases. In secretory cells, RRBP1-rich ER is responsible for the expansion of trans-Golgi network following the secretion of activated collagen.
特点和优势
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
联系
Corresponding Antigen APREST71890
外形
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
法律信息
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Clinical proteomics, 9(1), 7-7 (2012-06-20)
The molecular events that lead to malignant transformation and subsequent metastasis of breast carcinoma include alterations in the cells at genome, transcriptome and proteome levels. In this study, we used publicly available gene expression databases to identify those candidate genes
Experimental cell research, 316(3), 329-340 (2009-11-26)
A coiled-coil endoplasmic reticulum (ER) protein, p180, was originally reported as a ribosome-binding receptor on the rough ER and is highly expressed in secretory tissues. Recently, we reported new functions of p180 as a microtubule-bundling protein on the ER. Here
British journal of cancer, 113(5), 763-772 (2015-07-22)
Ribosome-binding protein 1 (RRBP1) has been implicated in the regulation of unfolded protein response, which is involved in almost every aspect of cancer development. We aimed to explore the significance of RRBP1 in the progression and prognosis of colorectal cancer
PLoS biology, 10(5), e1001336-e1001336 (2012-06-09)
In metazoans, the majority of mRNAs coding for secreted and membrane-bound proteins are translated on the surface of the endoplasmic reticulum (ER). Although the targeting of these transcripts to the surface of the ER can be mediated by the translation
Cancer cell, 39(11), 1479-1496 (2021-10-16)
Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A, -N, and -P, respectively). To define the heterogeneity of tumors and their associated microenvironments across subtypes, we sequenced
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门