HPA008791
抗MYBL1 兔抗
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
兔抗
产品名称
抗MYBL1 兔抗, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
technique(s)
immunohistochemistry: 1:50- 1:200
immunogen sequence
EANAVLSSLQTIPEFAETLELIESDPVAWSDVTSFDISDAAASPIKSTPVKLMRIQHNEGAMECQFNVSLVLEGKKNTCNGGNSEAVPLTSPNIAKFSTPPAILRKKRKMRVGHSPGSELRDGSLNDGGN
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MYBL1(4603)
Application
兔抗MYBL1抗体属Prestige抗体，经人类蛋白质图谱（HPA）计划开发和验证。每种抗体都通过针对数百种正常和疾病组织的免疫组织化学进行测试。通过单击图像库链接，可以在人类蛋白质图谱（HPA）站点上查看这些图像。还采用免疫荧光和蛋白质印迹法对抗体进行检测。想要查看有关Prestige 抗体和HPA的方案和其他实用信息，请访问 sigma.com/prestige。
在人类蛋白质图集项目网站上单击图像库链接，可以查看这些图像和庞大的数据集。我们还提供Prestige Antibodies® 抗体的实验方案和其他有用信息。
Biochem/physiol Actions
MYBL1 （v-myb鸟髓细胞组织增生病毒癌基因同源物样蛋白1）在28%的弥漫型星形细胞瘤II级肿瘤中部分复制。该基因的特征是在儿童低级别胶质瘤（pediatric low-grade glioma）中复发性癌基因截短重排（recurrent oncogenic truncating rearrangement）。一般认为该基因参与普通B细胞和Burkitt淋巴瘤的分化和增殖的控制。 它也可作为CBP（CREB结合蛋白）蛋白的相互作用分子伴侣，其带电序列结合了CBP的CREB （cAMP响应元件结合蛋白）结合结构域。
Disclaimer
除非我们的目录或随附于产品的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
Prestige抗体®是经过高度表征和广泛验证的抗体，同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige抗体对其他蛋白质的独特性和低交叉反应性®是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。针对每一个Prestige 抗体都存在有对应的Prestige抗原对照，并可在链接区域内找到。
每个Prestige 抗体都是按照以下方法进行测试的：
每个Prestige 抗体都是按照以下方法进行测试的：
- 44例正常人类组织以及20例最常见癌症类型组织的IHC组织阵列。
- 364个人类重组蛋白片段的蛋白阵列。
General description
MYBL1（v-myb禽成髓细胞病病毒致癌基因同源样1）基因定位于人类染色体8q13.1，编码一个转录因子。它是肿瘤蛋白家族Myb的一员。其N端包含DNA结合重复序列，C端包含两个保守区域。它的C-Myb交换激活域包含一个假定的亮氨酸拉链。
Immunogen
Myb 相关蛋白A重组蛋白表位信号标签（PrEST）
Other Notes
相应抗原APREST71002
Physical form
溶于含有40%甘油和0.02%叠氮化钠的磷酸盐缓冲盐水（pH 7.2）。
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
WGK 1
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Yoshitsugu Mitani et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 22(3), 725-733 (2015-12-04)
Adenoid cystic carcinoma (ACC) is an indolent salivary gland malignancy, characterized by t(6;9) translocations and MYB-NFIB gene fusions in approximately 50% of the tumors. The genetic alterations underlying t(6;9)-negative and t(6;9)-positive/MYB-NFIB fusion-negative ACC remain unknown. To uncover the genetic alterations
Muhammad Assad Riaz et al.
American journal of translational research, 9(3), 1266-1276 (2017-04-08)
Clusterin (CLU) is a ubiquitously expressed heterodimeric glycoprotein that is involved in a variety of functions like cell-cell interactions, apoptosis, epithelial-mesenchymal transition, carcinogenesis, and chaperone function. In the testis, CLU is strongly expressed especially in Sertoli cells but very little
Kentaro Takada et al.
International journal of cancer, 148(1), 193-202 (2020-09-29)
To generate a reliable preclinical model system exhibiting the molecular features of salivary adenoid cystic carcinoma (ACC) whose biology is still unclear due to the paucity of stable cell cultures. To develop new in vitro and in vivo models of
Lori A Ramkissoon et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(20), 8188-8193 (2013-05-02)
Pediatric low-grade gliomas (PLGGs) are among the most common solid tumors in children but, apart from BRAF kinase mutations or duplications in specific subclasses, few genetic driver events are known. Diffuse PLGGs comprise a set of uncommon subtypes that exhibit
Robin Kohler et al.
Nucleic acids research, 52(12), 6830-6849 (2024-05-15)
A-MYB (MYBL1) is a transcription factor with a role in meiosis in spermatocytes. The related B-MYB protein is a key oncogene and a master regulator activating late cell cycle genes. To activate genes, B-MYB forms a complex with MuvB and
相关内容
Prestige Antibodies Immunofluorescence Procedure
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持