产品名称
抗-SCGN 兔抗, affinity isolated antibody, buffered aqueous glycerol solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
human
technique(s)
immunohistochemistry: 1:500-1:1000
western blot: 0.04-0.4 μg/mL
immunogen sequence
RDLFLHHKKAISEAKLEEYTGTMMKIFDRNKDGRLDLNDLARILALQENFLLQFKMDACSTEERKRDFEKIFAYYDVSKTGALEGPEVDGFVKDMMELVQPSISGVDLDKFREILLRHCDVNKDGKIQKSELALCLGLK
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SCGN(10590)
Application
兔抗SCGN抗体属Prestige抗体，经人类蛋白质图谱（HPA）计划开发和验证。每种抗体都通过针对数百种正常和疾病组织的免疫组织化学进行测试。通过单击图像库链接，可以在人类蛋白质图谱（HPA）站点上查看这些图像。还采用免疫荧光和蛋白质印迹法对抗体进行检测。想要查看有关Prestige 抗体和HPA的方案和其他实用信息，请访问 sigma.com/prestige。
成功使用该抗体的应用以及相关的同行评审论文如下所示。
蛋白质免疫印迹分析（1篇论文）
蛋白质免疫印迹分析（1篇论文）
Biochem/physiol Actions
SCGN（促泌素）主要在Ca2+诱导的神经元和神经内分泌细胞的胞吐作用和膜融合中充当钙离子传感器。它可以结合四个Ca2+离子，但仅与一个SCGN相互作用的蛋白相互作用。作为识别神经元损伤的血清标志物。据报道，SCGN可以通过反映细胞对微环境刺激的反应来控制细胞内Ca2+信号传导途径。此外，SCGN的神经保护作用也已在阿尔茨海默氏′病中得到证明。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
Prestige Antibodies®是经过高度表征和广泛验证的抗体，同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige Antibodies®对其他蛋白质的独特性和低交叉反应性是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。每种Prestige 抗体都有相应的Prestige 抗原对照品，可在链接部分找到。
每种Prestige 抗体的检测方法如下：
每种Prestige 抗体的检测方法如下：
- 44种正常人体组织和20种最常见癌症组织的IHC组织阵列。
- 364个人重组蛋白片段的蛋白阵列。
General description
SCGN（促泌素）是一种新型的EF手，细胞类型特异性，Ca结合蛋白（CBP）。它在神经内分泌细胞中表达。具体而言，已经报道了其在外周和哺乳动物脑中的（肠）-内分泌细胞和神经内分泌细胞中的表达。它参与细胞内Ca2+动力学的调节。它包含一个Ca2+结合域和六个推定的EF手基序。
Immunogen
促泌素重组蛋白表位信号标签（PrEST）
Other Notes
相应抗原APREST86799
Physical form
溶于磷酸盐缓冲生理盐水（pH 7.2），含有40%甘油和0.02%叠氮化钠的溶液
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
常规特殊物品
此项目有
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