Anti-ZSCAN4 antibody produced in rabbit

ZSCAN4 (zinc finger and SCAN domain containing 4) is localized to the shelterin complex, and is a telomere-associated protein. This gene is localized to human chromosome 19q13.43.

zinc finger and SCAN domain containing 4 recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

ZSCAN4 (zinc finger and SCAN domain containing 4) is linked with the maintenance of telomeres in cancer cells, and controls the expression of TRF2, POT1b, and Rap1 proteins in embryonic stem cells (ESCs). In normal cells, it controls the length of telomeres, and thus, is essential in maintaining the integrity and stability of genome. It acts as a specific marker of ESCs and two-cell embryo stage. Inactivation of this gene results in shortening of telomeres, aberrations in karyotype, spontaneous sister chromatid exchange, and decreased cell proliferation.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST70996.

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

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