抗-DDX3X 兔抗

DEAD (Asp-Glu-Ala-Asp) box helicase 3 (DDX3X) is an ATP-dependent RNA helicase. It has multiple conserved domains and has roles in both the nucleus and cytoplasm.

ATP-dependent RNA helicase DDX3Y recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

DEAD (Asp-Glu-Ala-Asp) box helicase 3 (DDX3X) has RNA-unwinding and adenosine triphosphatase (ATPase) activities. The other functions include nuclear mRNA export, cell growth control and cancer progression. The ATPase activity of the helicase is stimulated by various ribo- and deoxynucleic acids. Studies with different nucleoside triphosphate analogs showed that the human DDX3 ATPase has high catalytic efficiency and rather relaxed substrate specificity, both in terms of base selection and sugar selection. It has an ability to recognize the L-stereoisomers of both 3′ deoxy- and 2′, 3′ dideoxy-ribose, showing it has low stereo selectivity.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST74303

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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