Anti-KIAA1217 antibody produced in rabbit

KIAA1217, also called SKT, is a human gene, which is homologous in nature to murine Sickle tail (Skt) gene. In mouse, the Skt gene is located in the proximal region of chromosome 2. However, in humans, the gene KIAA1217 is still designated as a hypothetical locus. SKT gene is expressed in intervertebral discs in the nucleus pulposa, in both humans and mice.

Sickle tail protein homolog recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

There is no known function of KIAA1217 gene as yet. SNP rs16924573 in SKT genes in human has been associated with Lumbar Disc Herniation (LDH). It has been suggested that abnormal SKT might be incapable of interacting with other proteins and forming cytoskeleton complexes, leading to nucleus pulposa dysfunction and LDH. SKT rs16924573 polymorphism, along with CLIP and IL6 polymorphisms, has been linked to disc degeneration (DD) in young adults. In Danforth′s short tail (sd) mutant mice, the incidence of anorectal malformations (ARMs) was increased to 100% by Skt mutations.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST70233

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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