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Merck
CN

HPA000701

Sigma-Aldrich

Anti-MNAT1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

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别名:
Anti-CDK-activating kinase assembly factor MAT1 antibody produced in rabbit, Anti-CDK7/cyclin H assembly factor antibody produced in rabbit, Anti-Cyclin G1-interacting protein antibody produced in rabbit, Anti-Ménage à trois antibody produced in rabbit, Anti-RING finger protein 66 antibody produced in rabbit, Anti-RING finger protein MAT1 antibody produced in rabbit, Anti-p35 antibody produced in rabbit, Anti-p36 antibody produced in rabbit
UNSPSC代码:
12352203
人类蛋白质图谱编号:
NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

形式

buffered aqueous glycerol solution

种属反应性

human

技术

immunohistochemistry: 1:50-1:200

免疫原序列

LDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHKLEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAG

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... MNAT1(4331)

免疫原

CDK-activating kinase assembly factor MAT1 recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

生化/生理作用

CDK-activating kinase assembly factor MAT1 is an enzyme encoded by the MNAT1 gene in humans and is localized to chromosome 14q23. The protein belongs to the cyclin-dependent kinase-activating kinase complex. It is functionally associated with the transcription/DNA repair factor TFIIH. It is an assembly factor that targets subunits of both cyclin-dependent kinase-activating kinase (CAK) and general transcription factor IIH (TFIIH) kinase. It regulates cell cycle and transcription.

特点和优势

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST70393

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

新产品

分析证书(COA)

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Siyue Lou et al.
Stem cells (Dayton, Ohio), 31(9), 1942-1953 (2013-06-15)
MAT1, an assembly factor and targeting subunit of both cyclin-dependent kinase-activating kinase (CAK) and general transcription factor IIH (TFIIH) kinase, regulates cell cycle and transcription. Previous studies show that expression of intact MAT1 protein is associated with expansion of human
Jiwei Wang et al.
The Journal of biological chemistry, 277(45), 43369-43376 (2002-09-06)
Cell cycle G(1) exit is a critical stage where cells commonly commit to proliferate or to differentiate, but the biochemical events that regulate the proliferation/differentiation (P/D) transition at G(1) exit are presently unclear. We previously showed that MAT1 (ménage à
T Eki et al.
Genomics, 47(1), 115-120 (1998-02-18)
Cyclin-dependent kinases (CDKs), which play a key role in cell cycle control, are activated by the CDK-activating kinase (CAK), which activates cyclin-bound CDKs by phosphorylation at the specific threonine residue. Mammalian CAK contains three components: CDK7, cyclin H, and an
V Gervais et al.
The Journal of biological chemistry, 276(10), 7457-7464 (2000-11-01)
The human MAT1 protein belongs to the cyclin-dependent kinase-activating kinase complex, which is functionally associated to the transcription/DNA repair factor TFIIH. The N-terminal region of MAT1 consists of a C3HC4 RING finger, which contributes to optimal TFIIH transcriptional activities. We

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