HPA000536

抗-SOX11 兔抗

Name: 抗-SOX11 兔抗
Brand: SIGMA

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

别名:

抗-Sry（Y染色体性别决定区）-盒11

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关于此项目

UNSPSC Code:

12352203

Human Protein Atlas Number:

HPA000536

NACRES:

NA.41

MDL number:

MFCD03097284

主要文件

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产品名称

抗-SOX11 兔抗, Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies^® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

technique(s)

immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:200-1:500

immunogen sequence

FMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRPRKKPKMDPSAKPSASQSPEKSAAGGGGGSAGGGAGGAKTSKGSSKK

UniProt accession no.

P35716

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... SOX11(6664)

Application

兔抗SOX11抗体可用于免疫组化和免疫印迹。

Biochem/physiol Actions

SOX11(SRY-box 11)在大脑发育中起重要作用。SOX11的缺失和新生突变会导致神经发育障碍，伴随Coffin−Siris综合征表现。该蛋白还在胚胎和成人神经发生、颅面骨生成、眼形态发生和心脏生长中起作用。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

Features and Benefits

Prestige Antibodies^®是经过高度表征和广泛验证的抗体，同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige Antibodies^®对其他蛋白质的独特性和低交叉反应性是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。每种Prestige 抗体都有相应的Prestige 抗原对照品，可在链接部分找到。

每种Prestige 抗体的检测方法如下：

44种正常人体组织和20种最常见癌症组织的IHC组织阵列。
364个人重组蛋白片段的蛋白阵列。

General description

SOX11 (SRY-box 11)是一种转录因子，含有一个高迁移率组(HMG)盒结构域。它定位于人类染色体2p25。该蛋白表达于中枢和周围神经系统、肺、胃肠道、胰、脾、肾、生殖腺和间充质。

Immunogen

转录因子SOX-11重组蛋白抗原表位标签(PrEST)

Other Notes

相应抗原APREST76154

Physical form

磷酸盐缓冲盐水溶液，pH 7.2，含有40%甘油和0.02%叠氮化钠

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品

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历史批次信息供参考:

分析证书(COA)

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Deletions and de novo mutations of SOX11 are associated with a neurodevelopmental disorder with features of Coffin-Siris syndrome.

Hempel A, et al.

Journal of medical Genetics, 53(3), 152-162 (2016)

Persistence of a t(11;14)-positive clone in a patient with mantle cell lymphoma for 20 years.

Yasuyuki Otsuka et al.

Clinical case reports, 5(4), 477-481 (2017-04-12)

We report here a patient with extremely indolent mantle cell lymphoma (MCL) who had progressed and required immunochemotherapy 20 years after diagnostic splenectomy. Non-nodal, indolent MCL patients may progress after such an extraordinary long indolent phase, and we recommend lifelong follow

Impact of Sox11 over-expression in Ba/F3 cells.

Martin Lord et al.

Haematologica, 103(12), e594-e597 (2018-06-30)

Duplication 2p25 in a child with clinical features of CHARGE syndrome.

Sperry ED, et al.

American Journal of Medical Genetics, 170(5), 1148-1154 (2016)

SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive mantle cell lymphoma.

Vegliante MC, et al.

Blood, 28(11), 2012-2012 (2013)

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商品

Mesenchymal Stem Cell Markers and Antibodies

Mesenchymal stem cell markers and antibodies suitable for investigating targets in fibroblasts, chondrocytes, adipocytes, osteoblasts, and muscle cells.

抗-SOX11 兔抗

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

选择尺寸

关于此项目

主要文件

属性

产品名称

biological source

conjugate

antibody form

antibody product type

clone

product line

form

species reactivity

technique(s)

immunogen sequence

UniProt accession no.

shipped in

storage temp.

target post-translational modification

Quality Level

Gene Information

相关类别

说明

Application

Biochem/physiol Actions

Disclaimer

Features and Benefits

General description

Immunogen

Other Notes

Physical form

Legal Information

安全信息

存储类别

wgk

flash_point_f

flash_point_c

ppe

法规信息

文件

分析证书(COA)

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Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution