推荐产品
产品线
MISSION®
形式
solid
成熟序列
UAGCUUAUCAGACUGAUGUUGA
Sanger mature/minor 登记号
Sanger microRNA登记号
储存温度
−20°C
基因信息
一般描述
即用型MISSION miRNA模拟物是小的双链RNA分子，旨在模拟导入细胞时的内源性成熟miRNA分子。已知miRNA以多种方式调节基因表达，包括翻译抑制，mRNA裂解和去腺苷酸化。MISSION miRNA模拟物是MISSION RNAi产品家族的成员，为miRNA研究人员提供了一系列选择，从单个MISSION Mimics到基于最新版本miRBase的完整人类miRNA 模拟物库（目前由曼彻斯特大学主办，以前由桑格研究所主办）。
- 优化并准备进行转染。
- 新型MISSION miRNA模拟设计已在功能上测试了针对天然miRNA靶标的敲低效率。
- 独特的MISSION miRNA模拟设计显著降低了可能的有义链脱靶效应。
- 可作为整个人类文库和单个miRNA靶标获得。
其他说明
miRBase V18 Mature ID update: hsa-miR-21-5p
法律信息
MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Lina Cai et al.
Oncology letters, 15(4), 5213-5219 (2018-03-20)
Numerous studies have indicated that microRNAs (miRs), a group of small non-coding RNAs, are determining regulatory elements involved in the pathogenesis of various types of cancer, including cervical cancer (CC). Although miR-21-5p upregulation has been demonstrated to associate with tumorigenesis
Microvesicles Derived from Adult Human Bone Marrow and Tissue Specific Mesenchymal Stem Cells Shuttle Selected Pattern of miRNAs
Collino F., Deregibus M.C., Bruno S., Sterpone L., Aghemo G., et al.
PLoS ONE, 5 (2010)
C Probert et al.
Oncogene, 38(10), 1751-1763 (2018-10-26)
The role of extracellular vesicles (EVs) as vehicles for cell-to-cell communication between a tumour and its environment is a relatively new concept. The hypothesis that EVs may be critical in co-opting tissues by tumours to generate distant metastatic niches is
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