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Merck
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安全信息

HMI0254

Sigma-Aldrich

MISSION® microRNA Mimic

hsa-miR-155

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别名:
hsa-miR-155-5p
UNSPSC代码:
12352200
miRNA ID:
hsa-mir-155 Sanger Database
NACRES:
NA.51

产品线

MISSION®

形式

solid

成熟序列

UUAAUGCUAAUCGUGAUAGGGGU

Sanger mature/minor 登记号

MIMAT0000646

Sanger microRNA登记号

MI0000681

储存温度

−20°C

基因信息

一般描述

即用型MISSION miRNA模拟物是小的双链RNA分子，旨在模拟导入细胞时的内源性成熟miRNA分子。已知miRNA以多种方式调节基因表达，包括翻译抑制，mRNA裂解和去腺苷酸化。MISSION miRNA模拟物是MISSION RNAi产品家族的成员，为miRNA研究人员提供了一系列选择，从单个MISSION Mimics到基于最新版本miRBase的完整人类miRNA 模拟物库（目前由曼彻斯特大学主办，以前由桑格研究所主办）。

  • 优化并准备进行转染。
  • 新型MISSION miRNA模拟设计已在功能上测试了针对天然miRNA靶标的敲低效率。
  • 独特的MISSION miRNA模拟设计显著降低了可能的有义链脱靶效应。
  • 可作为整个人类文库和单个miRNA靶标获得。

生化/生理作用

The miRNA hsa-miR-155-5p is a hypoxia-inducible oncomir which particularly targets the 3′UTR of the HIF1α (hypoxia-inducible factor 1-α) mRNA. It also targets pVHL (von Hippel Lindau tumour suppressor protein), thereby controlling hypoxic response pathways. The miRNA hsa-miR-155-5p controls ELK3 (ETS domain-containing protein) expression under hypoxia. It also regulates the expression of TFAM (transcription factor A, mitochondrial) and thereby regulates mitochondrial biogenesis in diploid cells. The miRNA hsa-miR-155-5p is upregulated in active MS (multiple sclerosis) lesions.

其他说明

miRBase V18 Mature ID update: hsa-miR-155-5p

法律信息

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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Integration of MicroRNA databases to study MicroRNAs associated with multiple sclerosis.
Angerstein C
Molecular Neurobiology, 45, 520-520 (2012)
The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response.
Robertson ED
PLoS ONE, 9, e113050-e113050 (2014)
Yujia Shi et al.
Allergy, asthma & immunology research, 10(3), 260-267 (2018-04-21)
Molecular mechanisms leading to asthma is still ill-defined. Though the function of microRNAs (miRNAs) in asthma was previously reported, the involvement of miR-155 in important features of this disease remains unknown. The present study was designed to uncover the probable
Xiang Song et al.
Acta biochimica et biophysica Sinica, 51(4), 386-392 (2019-03-07)
LncRNA NEF has been proved to be a tumor suppressor in liver cancer. In the present study, we found that lncRNA NEF was downregulated and miRNA-155 was upregulated in plasma of triple-negative breast cancer (TNBC) patients compared with those in
Adolfo Quiñones-Lombraña et al.
Biochimica et biophysica acta, 1852(7), 1420-1427 (2015-04-15)
The regulation of mitochondrial biogenesis is under the control of nuclear genes including the master Mitochondrial Transcription Factor A (TFAM). Recent evidence suggests that the expression of TFAM is regulated by microRNAs (miRNAs) in various cellular contexts. Here, we show

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