推荐产品
产品线
MISSION®
表单
solid
成熟序列
UUAAUGCUAAUCGUGAUAGGGGU
Sanger mature/minor 登记号
Sanger microRNA登记号
储存温度
−20°C
基因信息
一般描述
即用型MISSION miRNA模拟物是小的双链RNA分子，旨在模拟导入细胞时的内源性成熟miRNA分子。已知miRNA以多种方式调节基因表达，包括翻译抑制，mRNA裂解和去腺苷酸化。MISSION miRNA模拟物是MISSION RNAi产品家族的成员，为miRNA研究人员提供了一系列选择，从单个MISSION Mimics到基于最新版本miRBase的完整人类miRNA 模拟物库（目前由曼彻斯特大学主办，以前由桑格研究所主办）。
- 优化并准备进行转染。
- 新型MISSION miRNA模拟设计已在功能上测试了针对天然miRNA靶标的敲低效率。
- 独特的MISSION miRNA模拟设计显著降低了可能的有义链脱靶效应。
- 可作为整个人类文库和单个miRNA靶标获得。
生化/生理作用
The miRNA hsa-miR-155-5p is a hypoxia-inducible oncomir which particularly targets the 3′UTR of the HIF1α (hypoxia-inducible factor 1-α) mRNA. It also targets pVHL (von Hippel Lindau tumour suppressor protein), thereby controlling hypoxic response pathways. The miRNA hsa-miR-155-5p controls ELK3 (ETS domain-containing protein) expression under hypoxia. It also regulates the expression of TFAM (transcription factor A, mitochondrial) and thereby regulates mitochondrial biogenesis in diploid cells. The miRNA hsa-miR-155-5p is upregulated in active MS (multiple sclerosis) lesions.
其他说明
miRBase V18 Mature ID update: hsa-miR-155-5p
法律信息
MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Integration of MicroRNA databases to study MicroRNAs associated with multiple sclerosis.
Angerstein C
Molecular Neurobiology, 45, 520-520 (2012)
The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response.
Robertson ED
PLoS ONE, 9, e113050-e113050 (2014)
Xiang Song et al.
Acta biochimica et biophysica Sinica, 51(4), 386-392 (2019-03-07)
LncRNA NEF has been proved to be a tumor suppressor in liver cancer. In the present study, we found that lncRNA NEF was downregulated and miRNA-155 was upregulated in plasma of triple-negative breast cancer (TNBC) patients compared with those in
Yujia Shi et al.
Allergy, asthma & immunology research, 10(3), 260-267 (2018-04-21)
Molecular mechanisms leading to asthma is still ill-defined. Though the function of microRNAs (miRNAs) in asthma was previously reported, the involvement of miR-155 in important features of this disease remains unknown. The present study was designed to uncover the probable
Adolfo Quiñones-Lombraña et al.
Biochimica et biophysica acta, 1852(7), 1420-1427 (2015-04-15)
The regulation of mitochondrial biogenesis is under the control of nuclear genes including the master Mitochondrial Transcription Factor A (TFAM). Recent evidence suggests that the expression of TFAM is regulated by microRNAs (miRNAs) in various cellular contexts. Here, we show
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