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H9914

HIS-Select^® 镍磁性琼脂糖珠

Name: HIS-Select<SUP>®</SUP> 镍磁性琼脂糖珠
Brand: SIGMA

别名:

nickel charged magnetic beaded agarose

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About This Item

UNSPSC代码:

41106500

NACRES:

NA.56

偶联物

magnetic beads

质量水平

200

形式

suspension

保质期

2 yr (Unopened product)

基质

6% beaded magnetic agarose

容量

≥15 mg/mL binding capacity

储存温度

2-8°C

一般描述

HIS-选择性磁性琼脂糖珠由顺磁性的固定化金属离子亲和色谱（IMAC）树脂组成，包含专有的四配位体螯合物，与镍结合，通过不带电荷的亲水性连接子共价附于磁性珠状琼脂糖上。磁珠的磁性有助于操作，例如可反复清洗和回收与蛋白结合的磁珠。这使得实验重现性更高，更准确地定量组氨酸标记的目标蛋白。

应用

HIS-选择性镍磁性琼脂糖珠设计用于组氨酸标记蛋白的自动化和小规模亲和捕获（分子pull-down）纯化，同时表现出与其他蛋白非特异性结合低。该珠可在天然和变性条件下纯化His标签蛋白。

外形

以30%乙醇溶液中的50%浆液悬浮液的形式提供。

法律信息

HIS-Select is a registered trademark of Merck KGaA, Darmstadt, Germany

08168

Timestrip Plus^™ 8 °C温度指示标签

象形图

GHS02,GHS08,GHS07

警示用语：

Danger

危险声明

H226,H317,H350,H360D,H373,H412

预防措施声明

P202 - P210 - P273 - P280 - P303 + P361 + P353 - P308 + P313

危险分类

Aquatic Chronic 3 - Carc. 1B - Flam. Liq. 3 - Repr. 1B - Skin Sens. 1 - STOT RE 2

靶器官

Respiratory Tract

WGK

WGK 3

闪点(°F)

86.0 °F

闪点(°C)

30 °C

法规信息

危险化学品

分析证书(COA)

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Science signaling, 12(567) (2019-02-07)

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Clinical epigenetics, 7, 19-19 (2015-03-13)

Primary cells enter replicative senescence after a limited number of cell divisions. This process needs to be considered in cell culture experiments, and it is particularly important for regenerative medicine. Replicative senescence is associated with reproducible changes in DNA methylation

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American journal of respiratory cell and molecular biology, 41(6), 714-721 (2009-03-17)

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Nature, 519(7544), 425-430 (2015-03-25)

Cell migration is a stepwise process that coordinates multiple molecular machineries. Using in vitro angiogenesis screens with short interfering RNA and chemical inhibitors, we define here a MAP4K4-moesin-talin-β1-integrin molecular pathway that promotes efficient plasma membrane retraction during endothelial cell migration.

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Journal of materials chemistry. B, 1(15), 2066-2071 (2013-04-21)

The imidazolium cation was chosen as protein selective affinity group and a kind of ionic liquid magnetic microspheres was developed by immobilizing imidazolium cations onto the surface of silica-coated magnetic microspheres to form imidazolium ionic liquid modified magnetic microspheres (Fe3O4@SiO2@IL).

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