推荐产品
检测方案
≥98% (HPLC)
形式
powder
颜色
white to light yellow
溶解性
DMSO: >20 mg/mL
储存温度
2-8°C
SMILES字符串
CCCCCC(=O)c1c(O)cc(O)c(C(=O)CCCCC)c1O
InChI
1S/C18H26O5/c1-3-5-7-9-12(19)16-14(21)11-15(22)17(18(16)23)13(20)10-8-6-4-2/h11,21-23H,3-10H2,1-2H3
InChI key
JRHOSBCIYWDGHN-UHFFFAOYSA-N
生化/生理作用
贯叶金丝桃素是圣约翰草的活性成分。它被用于治疗抑郁症，已知可间接抑制突触的 5-羟色胺和去甲肾上腺素的再摄取，最近发现它通过直接激活 TRPC6 而发挥作用。TRPC6 是经典瞬时感受器电位 (TRPC) 离子通道家族的一员。DAG 是该通道的内源性激活剂，而贯叶金丝桃素是目前已知的唯一 TRPC6 选择性激活剂。尽管它应用广泛，但贯叶金丝桃素的化学结构不稳定。人们努力寻找一种稳定但药理相似的 TRPC6 激活剂，结果发现了 Hyp9，一种简化的间苯三酚衍生物。像贯叶金丝桃素一样，Hyp9 抑制血清素再摄取并诱导神经突生长。增加钙条目细胞并选择性增加通过 TRPC6 通道的电流。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Evan W Weber et al.
The Journal of experimental medicine, 212(11), 1883-1899 (2015-09-24)
Leukocyte transendothelial migration (TEM) is a tightly regulated, multistep process that is critical to the inflammatory response. A transient increase in endothelial cytosolic free calcium ion concentration (↑[Ca(2+)]i) is required for TEM. However, the mechanism by which endothelial ↑[Ca(2+)]i regulates
Lu Liu et al.
Frontiers in cell and developmental biology, 8, 594283-594283 (2021-02-20)
Transient receptor potential canonical 6 (TRPC6) channel is an important non-selective cation channel with a variety of physiological roles in the central nervous system. Evidence has shown that TRPC6 is involved in the process of experimental stroke; however, the underlying
商品
We offer many products related to transient receptor potential channels for your research needs.
我们提供许多血清素受体相关产品，满足您的各类研究需求。
We offer many products related to serotonin receptors for your research needs.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门