推荐产品
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen ~40 kDa
种属反应性
human
浓度
~1.0 mg/mL
技术
western blot: 0.5-1 μg/mL using using lysates of HEK-293T cells over-expressing human HOXA5
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... HOXA5(3202)
mouse ... Hoxa5(15402)
rat ... Hoxa5(79241)
一般描述
Homeobox A5 (HOXA5) is mapped to human chromosome 7p15.2. It belongs to amino acid Antennapedia (Antp) -class homeodomain proteins.
应用
Anti-HOXA5 antibody produced in rabbit has been used in immunoblotting.
生化/生理作用
Homeobox A5 (HOXA5) mediates organogenesis and development of mammary glands, lungs, digestive tract and thyroid. It is essential for ovary homeostasis. Mutation in HOXA5 gene hampers organogenesis as it affects axial specification in the cervico-thoracic level. HOXA5 has been shown to play an important role in breast tumorigenesis. It also regulates hematopoiesis by interacting with pleiotrophin (PTN).
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
Effect of silencing HOXA5 gene expression using RNA interference on cell cycle and apoptosis in Jurkat cells
Huang HP, et al.
International Journal of Molecular Medicine, 37(3), 669-678 (2016)
Identification of transcriptional targets of HOXA5
Chen H, et al.
The Journal of Biological Chemistry, 280(19), 19373-19380 (2005)
HOXA5-Mediated Stabilization of II?BI? Inhibits the NF-I?B Pathway and Suppresses Malignant Transformation of Breast Epithelial Cells.
Pai, et al.
Cancer research, 82, 3802-3814 (2023)
Compromised HOXA5 function can limit p53 expression in human breast tumours
Raman V, et al.
Nature, 405(6789), 974-974 (2000)
Hoxa5: a key player in development and disease
Jeannotte L, et al.
Journal of developmental biology, 4(2), 13-13 (2016)
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