product name
次黄嘌呤, powder, BioReagent, suitable for cell culture
产品线
BioReagent
质量水平
检测方案
≥99%
形式
powder
技术
cell culture | mammalian: suitable
mp
>300 °C (lit.)
溶解性
formic acid: water (2:1): 50 mg/mL
SMILES字符串
O=C1NC=Nc2nc[nH]c12
InChI
1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
InChI key
FDGQSTZJBFJUBT-UHFFFAOYSA-N
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一般描述
次黄嘌呤(6-羟嘌呤)，一种嘌呤衍生物，是天然化合物。它是腺嘌呤的脱氨基形式，也是一磷酸腺苷(AMP)的分解产物。
应用
次黄嘌呤是一种营养添加剂，适用于细菌、寄生虫（恶性疟原虫）和动物细胞等多种细胞培养应用。 次黄嘌呤是杂交瘤技术所用选择培养基的组分。
次黄嘌呤已被用于：
- 作为HEPES (4-(2-羟乙基)-1-哌嗪乙烷磺酸) -buffered Roswell park memorial institute (RPMI)补充剂，培养镰状疟原虫菌株IT/FCR3
- 制备Dulbecco′改性′s培养基 (DMEM) + MXH，用于选择嵌合修饰痘苗病毒安卡拉株(MVA)
- 产生超氧阴离子
- 用于制备杂交瘤选择和维持培养基。
生化/生理作用
次黄嘌呤能够刺激细胞死亡。它也能诱导活性氧(ROS)。通过氧化应激刺激细胞凋亡可导致内皮功能障碍。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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Hypoxanthine causes endothelial dysfunction through oxidative stress-induced apoptosis
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The ability of Paracoccidioides to defend itself against reactive oxygen species (ROS) produced by host effector cells is a prerequisite to survive. To counteract these radicals, Paracoccidioides expresses, among different antioxidant enzymes, superoxide dismutases (SODs). In this study, we identified
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