推荐产品
一般描述
血红素结合蛋白（HPX）由中央神经紧张的系统的细胞产生。它是一种60 kDa的血清糖蛋白。
应用
来自人血浆的血红素结合蛋白已经使用金黄色葡萄球菌表面定植测定。它也已被用于刺激混合淋巴细胞，以确定急性排斥反应中的生物标志物。
生化/生理作用
血红素结合蛋白是一种急性期蛋白，通过其血红素清除活性对氧化强制降解起主要保护作用。血红蛋白以高亲和力结合血红素，对于回收与血红素分子结合的铁以及防止血红素诱导的细胞损伤至关重要。 游离血红素从血红蛋白等蛋白质中释放或丢失后，可以催化活性氧的形成。 血红素是亲脂性的，并相互螯合到脂质膜中，并参与高毒性羟基自由基的形成。 血红素结合蛋白还可以防止血红素介导的LDL胆固醇氧化。
血红素结合蛋白还可以通过活化巨噬细胞对IL-6和TNF-α分泌的负调节来发挥抗炎作用。
血红素结合蛋白还可以通过活化巨噬细胞对IL-6和TNF-α分泌的负调节来发挥抗炎作用。
外形
含有钠磷酸盐、NaCl和KCl、pH值7.4的冻干粉
免责声明
仅供研究使用。本品在法国的科研应用受到监管，包括用于进口和出口活动（法国《公共卫生法典》Public Health Code Article L 1211-1 paragraph 2）。如《公共卫生法典》所述，购买者（即最终用户）需要从法国研究部(France Ministry of Research)获得进口授权。订购此产品即代表您已确认获得合法的进口授权。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Tirthartha Chattopadhyay et al.
Biochemical and biophysical research communications, 420(4), 862-868 (2012-04-03)
Proteins containing hemopexin fold domain are suggested to have diverse functions in various living organisms. In order to investigate the structure and function of this type of protein in rice plant (Oryza sativa), the gene encoding a hemopexin fold protein
Paolo Ascenzi et al.
Biochemical and biophysical research communications, 428(2), 239-244 (2012-10-17)
Hemopexin (HPX) displays a pivotal role in heme scavenging and delivery to the liver. In turn, heme-Fe-hemopexin (HPX-heme-Fe) displays heme-based spectroscopic and reactivity properties. Here, kinetics and thermodynamics of cyanide binding to ferric and ferrous hexa-coordinate human plasma HPX-heme-Fe (HHPX-heme-Fe(III)
Hemopexin alleviates cognitive dysfunction after focal cerebral ischemia-reperfusion injury in rats
Dong B, et al.
BMC anesthesiology, 19(1), 13-13 (2019)
Laura Vicente-Vicente et al.
Toxicology, 304, 83-91 (2012-12-25)
Drug nephrotoxicity is a serious health and economic problem worldwide. Rats can be acutely sensitized to acute kidney injury (AKI) by subnephrotoxic treatments with potentially nephrotoxic drugs. Acquired sensitization to AKI poses a silent risk impossible to diagnose pre-emptively with
Aubrey J Cunnington et al.
Journal of immunology (Baltimore, Md. : 1950), 189(11), 5336-5346 (2012-10-27)
It is not known why people are more susceptible to bacterial infections such as nontyphoid Salmonella during and after a malaria infection, but in mice, malarial hemolysis impairs resistance to nontyphoid Salmonella by impairing the neutrophil oxidative burst. This acquired
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门