H9289
抗-组蛋白H3（N-末端） 兔抗
affinity isolated antibody, buffered aqueous solution
别名:
兔抗组蛋白H3, 组蛋白 H3 检测, 组蛋白 H3 检测抗体
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选择尺寸
关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
indirect immunofluorescence
western blot
western blot
Species reactivity:
human
Citations:
37
Technique(s):
indirect immunofluorescence: 2-4 μg/mL using A431 cells.
western blot: 0.2-0.5 μg/mL using PC12 cell lysate and A431 cell lysate.
western blot: 0.2-0.5 μg/mL using PC12 cell lysate and A431 cell lysate.
产品名称
抗-组蛋白H3（N-末端） 兔抗, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~17 kDa
species reactivity
human
enhanced validation
independent
Learn more about Antibody Enhanced Validation
technique(s)
indirect immunofluorescence: 2-4 μg/mL using A431 cells.
western blot: 0.2-0.5 μg/mL using PC12 cell lysate and A431 cell lysate.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HIST1H3A(8350)
Application
兔抗组蛋白H3（N-末端）抗体还可用于蛋白质印迹和天然染色质免疫沉淀检测。
Biochem/physiol Actions
组蛋白是DNA包装的结构支架。组蛋白H3在复制和DNA修复中起重要作用。与组蛋白家族的其他成员相比，组蛋白H3的翻译后修饰更多。该基因突变会引发小脑高级胶质瘤。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。
General description
抗组蛋白抗体H3（N端）特异性识别人类组蛋白H3 (~17kDa)。组蛋白H3/组蛋白簇1H3家族成员a (HIST1H3A)是组蛋白家族的核心成员。HIST1H3A由定位至人类染色体6p22.2上的基因所编码。该编码蛋白质由~136个氨基酸组成。
Immunogen
对应于人组蛋白H3的1-20位氨基酸的合成肽，与KLH偶联。
Other Notes
想要使用各种技术和制备方法都能获得最佳结果，我们推荐通过滴定确定最佳工作稀释度。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Preparation Note
如需连续使用，可在 2-8°C 下储存长达一个月。对于长期储存，冷冻工作等分试样。不建议反复冻融或储存在“无霜”冰柜中。如果延长储存时间后出现轻微浑浊，则在使用前离心澄清溶液。如果未在 12 小时内使用，则应丢弃工作稀释液。
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Phosphorylation of histone H3 Ser10 establishes a hierarchy
for subsequent intramolecular modification events
for subsequent intramolecular modification events
Liokatis S, et al.
Nature Structural and Molecular Biology, 19, 819-823 (2012)
Histone H3 K27M mutations in adult cerebellar high-grade gliomas.
Nakata S, et al.
Brain Tumor Pathology, 34, 113-119 (2017)
Rita A Batista et al.
eLife, 8 (2019-12-04)
MADS-box transcription factors (TFs) are ubiquitous in eukaryotic organisms and play major roles during plant development. Nevertheless, their function in seed development remains largely unknown. Here, we show that the imprinted Arabidopsis thaliana MADS-box TF PHERES1 (PHE1) is a master
Jordi Moreno-Romero et al.
The EMBO journal, 35(12), 1298-1311 (2016-04-27)
Parental genomes in the endosperm are marked by differential DNA methylation and are therefore epigenetically distinct. This epigenetic asymmetry is established in the gametes and maintained after fertilization by unknown mechanisms. In this manuscript, we have addressed the key question
H3K9me3-binding proteins are dispensable for SETDB1/H3K9me3-dependent retroviral silencing
Maksakova IA, et al.
Epigenetics & Chromatin, 4 (2011)
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