Application
小牛胸腺中的组蛋白已用于:
- 在甲基转移酶反应混合物中进行甲基转移酶测定
- 在体外结合试验中,探讨了MORF4(4号染色体上的死亡率因子)-15号染色体上相关基因(MRG15)与组蛋白的潜在结合
- 在体外共培养试验中刺激肝脏驻留的Kupffer细胞
Biochem/physiol Actions
核心组蛋白参与组蛋白-组蛋白各种相互作用并维持核小体DNA的组织。组蛋白尾巴有助于形成更高阶的核小体结构。染色质纤维的整体结构和作用受组蛋白修饰的调节。
Features and Benefits
不要将Sigma“类型”名称与Luck及其同事使用的“分级”名称混淆。
General description
组蛋白是含有H3、H4、H2A和H2B的八聚体蛋白。它是DNA是围绕其缠绕形成核小体结构的核心蛋白。核心组蛋白包含球状结构域。每个蛋白在其N端均由碱性氨基酸组成。H2A在其C末端具有一个额外的氨基酸,形成组蛋白尾巴。核小体结构在染色质浓缩过程中通过接头组蛋白稳定。
Preparation Note
未分级的全组蛋白
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury
Huang H, et al.
Journal of Immunology, 191(5), 2665-2679 (2013)
Juan-Carlos Cabrera et al.
Glycobiology, 20(6), 775-786 (2010-03-05)
Plant cell walls undergo remodeling during growth and development and are the first target of many invading pathogens. Acidic pectin (homogalacturonans) binds calcium and forms chain dimers called egg boxes and even multimers at higher calcium ion concentrations. Chitosan, the
Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3
Zhang P, et al.
Nucleic Acids Research, 34(22), 6621-6628 (2006)
Histones and histone modifications
Peterson CL, et al.
Current Biology, 14(14), R546-R551 (2004)
Yannick Tauran et al.
Scientific reports, 9(1), 5816-5816 (2019-04-11)
By means of Silicon Nano Tweezers (SNTs) the effects on the mechanical properties of λ-phage DNA during interaction with calf thymus nucleosome to form an artificial chromatin analog were measured. At a concentration of 100 nM, a nucleosome solution induced a
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