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重组
expressed in E. coli
质量水平
方案
≥95% (SDS-PAGE)
分子量
18 kDa
浓度
~1 mg/mL
UniProt登记号
储存温度
−20°C
基因信息
hepatitis B virus ... HBVgp4(944568)
human ... HBVgp4(944568)
一般描述
amino acids 1-183 of HBV core antigen.
生化/生理作用
HBcAg core human is a capsid protein of hepatitis B virus (HBV). It acts as a viral factor for HBV clearance. HBcAg is implicated in viral replication.
Hepatitis B virus core antigen (HBcAg) is a positive control for human HBV antibodies.In humans with chronic HBV (hepatitis B virus) infection, cytotoxic effects of blood T lymphocytes can be suppressed by incubating cells with antibodies against hepatitis B core antigen (HBcAg). The antigen can also work as a T-cell independent antigen in athymic mice. However, it is an efficient immunogen, resulting in T-cell activation and increased anti-HBc levels. High cytoplasmic/membranous expression of HBcAg is associated with increased liver inflammation.
外形
Solution in 50% glycerol, 7.5 mM phosphate buffer, pH 7.2, 75 mM NaCl.
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Long Liu et al.
Journal of medical virology (2020-02-23)
Hepatitis B virus (HBV) chronically infects approximately 350 million people worldwide, and 600 000 deaths are caused by HBV-related hepatic failure. Golgi protein 73 (GP73) is a serum biomarker for liver diseases, including chronic hepatitis B. Here, we determine the effect
J B Kurtz et al.
Journal of virological methods, 96(2), 127-132 (2001-07-11)
A measurable serological response to hepatitis C infection is delayed on average until 70 days after infection. In addition, it may not occur in some immunocompromised people. Detection of free hepatitis C (HCV) core antigen in blood has enabled diagnosis
C M Chu et al.
Gastroenterology, 92(1), 220-225 (1987-01-01)
The intrahepatic distribution of hepatitis B core antigen (HBcAg) and surface antigen (HBsAg) was studied in 32 patients with chronic type B hepatitis, and the results were correlated with the status of hepatitis B e antigen/antibody (HBeAg/anti-HBe) and with the
D R Milich et al.
Journal of immunology (Baltimore, Md. : 1950), 139(4), 1223-1231 (1987-08-15)
Hepatitis B virus nucleocapsid particles (HBcAg) can function as a T cell-independent antigen when injected into athymic mice. However, immunization of euthymic mice with HBcAg results in dramatically increased anti-HBc titers. Therefore we have examined the murine T cell response
M Mondelli et al.
Journal of immunology (Baltimore, Md. : 1950), 129(6), 2773-2778 (1982-12-01)
Peripheral blood T lymphocytes from 21 patients with chronic HBV infection were incubated with autologous hepatocytes in a microcytotoxicity assay. Cytotoxicity was significantly increased in 13 cases, and in 12 of these the cytotoxic effect of the T lymphocytes was
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