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Merck
CN

H8891

肝素酶III 来源于肝素黄杆菌

Lyophilized powder stabilized with approx. 25% (w/w) bovine serum albumin, ≥30 units/mg protein (enzyme + BSA)

别名:

肝素裂解酶III, 肝素酶 来源于肝素黄杆菌, 肝素酶I

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化学文摘社编号:
37290-86-1
UNSPSC Code:
12352204
NACRES:
NA.54
EC 号:
4.2.2.8 (BRENDA, IUBMB)
MDL number:
MFCD00131319

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产品名称

肝素酶III 来源于肝素黄杆菌, Lyophilized powder stabilized with approx. 25% (w/w) bovine serum albumin, ≥30 units/mg protein (enzyme + BSA)

biological source

bacterial (Flavobacterium heparinum)

conjugate

conjugate (Glucosaminoglycan)

form

lyophilized powder

specific activity

≥30 units/mg protein (enzyme + BSA)

mol wt

70.8 kDa

application(s)

diagnostic assay manufacturing

storage temp.

−20°C

Quality Level

200

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Application

肝素黄杆菌肝素酶III已用于裂解特定GAG。已用于研究其对与抗aFGF（酸性成纤维细胞生长因子）抗体反应的蛋白质的电泳迁移率的影响。

Biochem/physiol Actions

肝素酶III可防止体内新血管的形成。它在HNY-I和HNY、6X-G2连接处特异性降解硫酸肝素。与其他肝素酶不同，肝素酶III不含氨基酸半胱氨酸。它含有13个组氨酸残基，这是其催化作用的原因。该酶对肝素或低分子量肝素没有活性。
肝素降解裂解酶，识别硫酸肝素蛋白聚糖为其主要底物。

Other Notes

在25 °C、pH 7.5条件下，一个单位每小时可形成0.1 μM不饱和糖醛酸。一个国际单位（I.U.）相当于大约600个Sigma单位。包装规格基于Sigma单位。
更多关于复杂碳水化合物分析酶的信息请见www.sigma-aldrich.com/enzymeexplorer

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

低风险生物材料
常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000444454
0000444456
0000444456
0000444454
0000444458

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Is Product No. H8891, Heparinase III sold based on Sigma Units or International Units?

    This material is sold based on Sigma Units.  One Sigma Unit will form 0.1 μmole of unsaturated uronic acid per hr at pH 7.5 at 25 °C. One International Unit (I.U.) is equivalent to approx. 600 Sigma units.  

  6. Does Product No. H8891, Heparinase III, contain calcium?

    This product is lyophilized from a solution which is 75 mM NaCl/ 5mM NaH2PO4. We have no reason to believe that calcium ions are present.

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

FGF binding by extracellular matrix components of Wharton's jelly
Malkowski A, et al.
Acta Biochimica Polonica, 54(2), 357-357 (2007)
Erin M Smith et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(51), 21683-21688 (2009-12-08)
Platelet-derived growth factor (PDGF) signaling is essential for processes involving cell motility and differentiation during embryonic development in a wide variety of organisms including the mouse, frog, zebrafish, and sea urchin. In early Xenopus laevis embryos, PDGF-AA provides guidance cues
Fluid shear stress primes mouse embryonic stem cells for differentiation in a self-renewing environment via heparan sulfate proteoglycans transduction
Toh YC and Voldman J
Faseb Journal, 25(4), 1208-1217 (2011)
Andrea Garolla et al.
Human reproduction (Oxford, England), 27(4), 967-973 (2012-02-09)
Human papillomavirus (HPV) infection has been demonstrated in the sperm of a large percentage of sexually active males and is associated with an impairment of sperm parameters, with a particular negative impact on sperm motility, suggesting a possible role in
Composition of the endothelial glycocalyx and its relation to its thickness and diffusion of small solutes
Gao L and Lipowsky HH
Microvascular Research, 80(3), 394-401 (2010)
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