H8631
5-Hydroxymethyl-2′-deoxyuridine
≥95% (HPLC)
别名:
5-HMdU, HMdUdr
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关于此项目
经验公式（希尔记法）:
C10H14N2O6
化学文摘社编号:
分子量:
258.23
UNSPSC Code:
41106305
PubChem Substance ID:
EC Number:
225-848-0
MDL number:
InChI key
IPAVKOYJGUMINP-UHFFFAOYSA-N
InChI
1S/C10H14N2O6/c13-3-5-2-12(10(17)11-9(5)16)8-1-6(15)7(4-14)18-8/h2,6-8,13-15H,1,3-4H2,(H,11,16,17)
SMILES string
OCC1OC(CC1O)N2C=C(CO)C(=O)NC2=O
assay
≥95% (HPLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless to very faintly yellow
storage temp.
−20°C
Application
5-Hydroxymethyl-2′-deoxyuridine (HMdUdr) is a used as a marker for oxidative nucleic acid (DNA) damage. HMdUdr may be used as an antigen to create anti-HMdUdr antibodies.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Jin Wang et al.
Analytical chemistry, 83(6), 2201-2209 (2011-02-18)
The purpose of our study was to develop suitable methods to quantify oxidative DNA lesions in the setting of transition metal-related diseases. Transition metal-driven Fenton reactions constitute an important endogenous source of reactive oxygen species (ROS). In genetic diseases with
S Mitchell Harman et al.
Free radical biology & medicine, 35(10), 1301-1309 (2003-11-11)
To assess novel liquid chromatography/mass spectrometric methods for measuring oxidative damage to nucleic acids and lipids, we compared urinary excretion of 8-hydroxy-2'-deoxyguanosine (8-OHdG), 5-hydroxymethyl-2'-deoxyuridine (5-OHmU), and 8-hydroxyguanosine (8-OxoG), and an isoprostane, 8-iso-prostaglandin F(2)alpha (IsopF(2)alpha) in 234 healthy men (n =
Lisa S McAnulty et al.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 36(6), 976-984 (2011-11-25)
Blueberries are rich in antioxidants known as anthocyanins, which may exhibit significant health benefits. Strenous exercise is known to acutely generate oxidative stress and an inflammatory state, and serves as an on-demand model to test antioxidant and anti-inflammatory compounds. The
Mark D Evans et al.
Mutagenesis, 25(5), 433-442 (2010-06-05)
Monitoring oxidative stress in vivo is made easier by the ability to use samples obtained non-invasively, such as urine. The analysis of DNA oxidation, by measurement of oxidized 2'-deoxyribonucleosides in urine, particularly 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), has been reported extensively in the
Zora Djuric et al.
Toxicological sciences : an official journal of the Society of Toxicology, 66(1), 125-130 (2002-02-28)
Caloric restriction has previously been shown to decrease levels of oxidative stress in rats. In this study, we examined the effects of 5 different caloric intake levels on one type of oxidative DNA damage in rat mammary gland, blood, and
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