推荐产品
产品名称
Interleukin-23 human, IL-23, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
生物来源
human
质量水平
重组
expressed in HEK 293 cells
方案
≥95% (SDS-PAGE)
表单
lyophilized powder
效能
≤2 ng/mL EC50
质量
endotoxin tested
分子量
dimer 55 kDa (glycosylated)
包装
pkg of 5X10 μg
pkg of 10 μg
pkg of 5 μg
技术
cell culture | mammalian: suitable
杂质
≤1EU/mg
UniProt登记号
储存温度
−20°C
基因信息
human ... IL23A(51561)
相关类别
一般描述
HumanKine interleukin-23 (IL-23) is expressed as a heterodimeric 55 kDa cytokine composed of two glycosylated and disulfide linked subunits (p40 cystine linked to p19). Production in human HEK 293 cells offers authentic glycosylation. Cytokines produced in Sf9 or Sf21 cells have post-translational modifications, which are not human-like.
Interleukin-23 (IL-23) is a pro-inflammatory cytokine. It is mostly synthesized by activated dendritic cells and macrophages. It is a 20.7kDa protein with 189 amino acids. IL-23 is mostly expressed on activated/memory T cells and natural killer (NK) cells. This gene is located on human chromosome 12q13.3.
Interleukin-23 (IL-23) is a pro-inflammatory cytokine. It is mostly synthesized by activated dendritic cells and macrophages. It is a 20.7kDa protein with 189 amino acids. IL-23 is mostly expressed on activated/memory T cells and natural killer (NK) cells. This gene is located on human chromosome 12q13.3.
生化/生理作用
Interleukin-23 (IL-23) plays a major role in cutaneous immune-mediated inflammatory diseases like psoriasis, allergic contact dermatitis and atopic dermatitis. It is involved in cellular immunity, driving the expansion, stabilization and survival of Th17 cells.
分析说明
The specific activity was determined by the dose-dependent secretion of h-IFN-γ or IL-8 from human PBMC.
法律信息
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
储存分类代码
11 - Combustible Solids
WGK
WGK 1
法规信息
新产品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
IL23A (interleukin 23, alpha subunit p19)
Norimitsu I.
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 15(2) (2011)
Expression of IL-23/Th17-related cytokines in basal cell carcinoma and in the response to medical treatments
Cristina P, et al.
PLoS ONE, 12(8), e0183415-e0183415 (2017)
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