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生物来源
human
质量水平
重组
expressed in HEK 293 cells
检测方案
≥95% (SDS-PAGE)
形式
lyophilized
效能
≤2 ng/mL EC50
分子量
dimer 57 kDa (glycosylated)
包装
pkg of 10 μg
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
储存温度
−20°C
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应用
Interleukin-12 (IL-12) human has been used to study IL-12 mediated enhancement of IL-12Rβ2 (IL-12 receptor) expression.
生化/生理作用
Interleukin-12 (IL-12) was identified as a factor secreted by human Epstein-Barr (EBV)-transformed B cell lines. IL-12, or Natural Killer Cell Stimulatory Factor (NKSF), is a 75 kDa disulfide-linked heterodimer of a 35 kDa subunit and 40 kDa subunit. IL-12 is produced predominantly by monocytes and NK cells and induces T cells and NK cells to produce IFN-γ. Human IL-12 is not active on mouse cells, but murine IL-12 is active on both murine and human lymphocytes. The biological activity of recombinant human IL-12 was measured by its ability to stimulate the proliferation of PHA-activated human T lymphoblasts. IL-12 has anti-angiogenic properties.
外形
lyophilized from a 0.2 μm filtered solution of PBS
分析说明
The specific activity was determined by the dose-dependent release of IFN-γ from the human NK92 cell line in presence of 20 ng/mL rIL-2.
法律信息
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn's disease.
Matsuoka K et al.
Gut, 53, 1303-1303 (2004)
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