Anti-HIP14 兔抗

HIP14 (also known as zinc finger, DHHC domain containing protein 17 (ZDHHC17), huntingtin interacting protein H (HYPH), huntingtin interacting protein 3 (HIP3), HSPC294 and KIAA0946) is a novel htt interacting protein.

Huntingtin interacting protein 14 (HIP14) is a palmitoyl transferase (PAT) neuronal type, localizes to the Golgi, and to vesicles in the cytoplasm. HIP14 mRNA is predominantly expressed in the brain.

synthetic peptide corresponding to amino acids 614-632 located at the C-terminus of human HIP14. This sequence is identical in mouse, rat, dog, and bovine HIP14.

Anti-HIP14 antibody produced in rabbit has been used in quantitative immunoblotting, immunohistochemistry.

The interaction of huntingtin interacting protein 14 (HIP14) with huntingtin protein (htt) is inversely correlated to the polyQ length.. HIP14 along with htt is localized in striatum, medium spiny projection neurons. It is also associated neurons associated with Huntington disease (HD). HIP14 under expression in neurons reduces the clustering of postsynaptic density protein 95 (PSD-95) and glutamic acid decarboxylase 65-kilodalton isoform (GAD65). It has been suggested that HIP14 has a role in palmitoylation and in regulating the intracellular trafficking of multiple neuronal proteins. Decreased interaction between mutant htt and HIP14 could contribute to neuronal dysfunction in HD by perturbing normal intracellular transport pathways in neurons.

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

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