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一般描述
腹足类血青素是一种大型糖蛋白(4到8 MDa)，由10个亚基的复杂排列设计而成，这些亚基自组装成直径35纳米的空心圆柱体。
血青蛋白是一种高分子量的含铜糖蛋白。它可逆的与氧气结合，形成软体动物的细胞外呼吸蛋白。钉形贝血蓝蛋白(KLH)是由 巨齿蛇血淋巴过滤得到，也被称为巨星钥孔虫。它原产于南加州海岸和墨西哥。
应用
钉形贝血蓝蛋白(KLH)是一种在实验动物和人类中强大的和众所周知的免疫刺激剂。它已被用作半抗原载体蛋白，以增强抗原特异性T细胞启动，并已知可刺激CD4+ T细胞反应。血红素刺激Th1反应而没有已知的副作用，这使它们成为长期连续治疗癌症的理想药物。
外形
稳定缓冲盐冻干
重悬
采用去离子水复配KLH浓度为10 mg/mL，在含0.46 M NaCl、2% PVP和41 mM蔗糖的31 mM磷酸钠缓冲液，pH 7.4中，得到乳白色溶液。
复溶的蛋白溶液液可在−20°C保存长达2个月。
复溶的蛋白溶液液可在−20°C保存长达2个月。
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
J T Brisbin et al.
Poultry science, 87(10), 1995-1999 (2008-09-24)
Subtherapeutic and prophylactic doses of virginiamycin are capable of altering the intestinal microbiota as well as increasing several growth parameters in chickens. In spite of the fact that the microbiota plays a role in shaping the host's immune system, little
Robert J Huber et al.
Histochemistry and cell biology, 136(2), 177-189 (2011-07-19)
The Dictyostelium discoideum homolog of mammalian cyclin dependent kinase 5 (Cdk5) has previously been shown to be required for optimal growth and differentiation in this model organism, however, the subcellular localization of the protein has not previously been studied. In
Xiujuan Zhou et al.
Fish & shellfish immunology, 93, 641-651 (2019-07-26)
Interleukin-2 receptor subunit beta of flounder (Paralichthys olivace, fIL-2Rβ) was annotated on the NCBI, its gene was cloned and characterized functionally in this study. And then the amino acids sequences and tertiary structure of fIL-2Rβ were analyzed, respectively. RT-PCR and
Chloe C Josefson et al.
Integrative and comparative biology, 60(3), 732-741 (2020-08-21)
One of the key foci of ecoimmunology is understanding the physiological interactions between reproduction and immune defense. To assess an immune challenge, investigators typically measure an immune response at a predetermined time point that was selected to represent a peak
István Fodor et al.
General and comparative endocrinology, 299, 113621-113621 (2020-09-24)
In the last years, our interpretation of the origin and function of the gonadotropin-releasing hormone (GnRH) neuropeptide superfamily has changed substantially. A main driver for these conceptual changes came from increased investigations into functions and evolutionary lineage of previously identified
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