推荐产品
生物来源
human
质量水平
重组
expressed in HEK 293 cells
检测方案
≥95% (SDS-PAGE)
形式
lyophilized powder
效能
≤4 ng/mL EC50
质量
endotoxin tested
分子量
dimer 35-40 kDa (glycosylated)
包装
pkg of 10 μg
制造商/商品名称
HumanZyme
技术
cell culture | mammalian: suitable
UniProt登记号
储存温度
−20°C
基因信息
human ... CSF1(1435)
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一般描述
M-CSF由定位至人类染色体1p13.3上的基因所编码。它是一种糖基化多肽，以同二聚体的形式存在。M-CSF由巨噬细胞、成纤维细胞、淋巴细胞和内皮细胞产生。
生化/生理作用
巨噬细胞CSF (M-CSF)作为一种生长因子，刺激单核/巨噬细胞系细胞的增殖和分化。它还可增强抗体依赖、单核细胞和巨噬细胞介导的细胞毒性。此外，人M-CSF可抑制破骨细胞的骨吸收。它在动脉粥样硬化中也可能发挥关键作用。在骨骼Paget病(PDB)中观察到该基因的过表达。
外形
从0.2 μm过滤的 1x PBS溶液中冻干。
分析说明
通过鼠类TF-60 细胞（小鼠红白血病指示细胞系）增值的剂量依赖性刺激测定比活性。
引用
1.Mazur, E.M., and Cohen, J.L., Clin. Pharmacol.Ther., 46, 250 (1989).
2.Morstyn, G., and Burgess, A.W., Cancer Res., 48, 5624 (1988).
3.Metcalf, D., Blood, 67, 257 (1986).
4.Mufson, R.A., et al., Cell.Immunol., 119, 182 (1989).
5.Hattersley, G., et al., J. Cell Physiol., 137, 199 (1988).
2.Morstyn, G., and Burgess, A.W., Cancer Res., 48, 5624 (1988).
3.Metcalf, D., Blood, 67, 257 (1986).
4.Mufson, R.A., et al., Cell.Immunol., 119, 182 (1989).
5.Hattersley, G., et al., J. Cell Physiol., 137, 199 (1988).
法律信息
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone.
Albagha O M E, et al.
Nature Genetics, 429(6), 520-520 (2010)
"Effects of macrophage colony-stimulating factor (M-CSF) on protease production from monocyte, macrophage and foam cell in vitro: a possible mechanism for anti-atherosclerotic effect of M-CSF.
Tojo N, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1452.3, 275-284 (1999)
Macrophage colony-stimulating factor enhances monocyte and macrophage antibody-dependent cell-mediated cytotoxicity.
Mufson R A, et al.
Cellular Immunology, 119(1), 182-192 (1989)
Human macrophage colony-stimulating factor inhibits bone resorption by osteoclasts disaggregated from rat bone.
Hattersley G, et al.
Journal of Cellular Physiology, 137(1), 199-203 (1988)
Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes.
Rettenmier CW
Molecular and Cellular Biology, 7(7), 2378-2387 (1987)
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