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产品名称
角质细胞生长因子 人, KGF, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
生物来源
human
质量水平
重组
expressed in HEK 293 cells
方案
>95% (SDS-PAGE)
表单
lyophilized powder
效能
4-20 ng/mL EC50
质量
endotoxin tested
分子量
dimer 17-30 kDa (glycosylated)
包装
pkg of 10 μg
技术
cell culture | mammalian: suitable
杂质
<1 EU/μg
UniProt登记号
储存温度
−20°C
基因信息
human ... FGF7(2252)
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一般描述
Keratinocyte Growth Factor (KGF) belongs to the fibroblast growth factor 7 (FGF-7) family. It is produced by the mesenchymal cells, γδ T cells, and fibroblasts in several organs. The KGF gene is located on the human chromosome at 15q21.2.
应用
Keratinocyte Growth Factor (KGF) human has been used as a component of the keratinocyte differentiation medium.
生化/生理作用
Keratinocyte Growth Factor (KGF) exerts paracrine effects on mesenchymal cells. It exhibits cryoprotective effects on epithelial cells of the lungs, gastrointestinal tract, and the lungs. KGF participates in the activation of IIIb isoform of the fibroblast growth factor (FGF)-receptor 2 (FGFR2-IIIb) present on keratinocytes. This activation further favors proliferation, migration, and survival of keratinocytes.
外形
Lyophilized from a 0.2 μm filtered solution of 1x PBS.
制备说明
HumanKine Keratinocyte Growth Factor (KGF) is expressed as glycosylated 17 and 30 kDa monomers in human HEK 293 cells. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
分析说明
The activity was determined by the dose-dependent stimulation of the proliferation of 4MBr-5 cells (monkey epithelial cell line).
法律信息
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Qandeel Fatima et al.
Open life sciences, 13, 544-552 (2018-12-31)
Autologous skin grafts are used to treat severe burn wounds, however, the availability of adequate donor sites makes this option less practical. Recently, stem cells have been used successfully in tissue engineering and in regenerative medicine. The current study aims
Michael J LaFemina et al.
American journal of physiology. Lung cellular and molecular physiology, 299(6), L724-L734 (2010-09-14)
Keratinocyte growth factor (KGF) has efficacy in several experimental models of lung injury; however, the mechanisms underlying KGF's protective effect remain incompletely understood. This study was undertaken to determine whether KGF augments barrier function in primary rat alveolar epithelial cells
Umbilical cord tissue derived mesenchymal stem cells can differentiate into skin cells
Fatima Q, et al.
The Open Immunology Journal, 13(1), 544-552 (2018)
Susanne Braun et al.
Journal of cell science, 119(Pt 23), 4841-4849 (2006-11-09)
Owing to its potent cytoprotective properties for epithelial cells, keratinocyte growth factor (KGF) is successfully used for the treatment of chemotherapy- and radiotherapy-induced oral mucositis in cancer patients. It is therefore of major interest to determine possible clinical applications of
Verônica Chomiski et al.
Acta cirurgica brasileira, 31(8), 505-512 (2016-09-01)
To evaluate the effect of keratinocyte growth factor (KGF) treatment on the expression of wound-healing-related genes in cultured keratinocytes from burn patients. Keratinocytes were cultured and divided into 4 groups (n=4 in each group): TKB (KGF-treated keratinocytes from burn patients)
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