推荐产品
产品名称
Interferon α 2B human, IFN-α 2B, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
生物来源
human
质量水平
重组
expressed in HEK 293 cells
方案
≥95% (SDS-PAGE)
表单
lyophilized powder
效能
≤0.12 ng/mL EC50
质量
endotoxin tested
分子量
dimer 16 kDa (glycosylated)
包装
poly bottle of 10 μg (in poly bottle)
制造商/商品名称
HumanZyme
技术
cell culture | mammalian: suitable
杂质
≤1EU/mg
UniProt登记号
储存温度
−20°C
基因信息
human ... IFNA2(3440)
一般描述
The interferon α 2 (IFN-α2) exists in three forms 2a, 2b and 2c. It consists of 165 amino acids and five α helices. IFN-α2B is found structurally stable at pH 7. The recombinant IFN-α is nonglycosylated compared to the natural human IFN-α.
生化/生理作用
Interferon α 2B (IFN-α 2B) belongs to the type I interferon protein family. It is produced by many cell types in response to viral infection. IFN-α 2B has antiproliferative and antitumor activities, as well as induction of apoptosis and the inflammatory response. It enhances the expression of MHC proteins by increasing the presentation of antigen peptides and activates cytotoxic T-cells.
外形
Lyophilized from a 0.2 μm filtered solution of 1x PBS.
制备说明
HumanKine IFN-α 2B is a glycosylated monomer expressed in HEK 293 cells with an apparent molecular mass of 16 kDa. Production in human 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
分析说明
The specific activity was determined by the dose-dependent proliferation of WISH (heteroploid human amnion cell line) in presence of VSV ( vesicular stomatitis virus).
法律信息
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
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A R Mire-Sluis et al.
Journal of immunological methods, 195(1-2), 55-61 (1996-09-09)
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