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生物来源
human
质量水平
检测方案
≥95% (HPLC)
形式
powder
分子量
2654.2-2660.2 Da
储存条件
(Keep container tightly closed in a dry and well-ventilated place)
技术
activity assay: suitable
溶解性
water: 1.00-1.04 mg/mL, clear, colorless
运输
dry ice
储存温度
−20°C
Amino Acid Sequence
Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
一般描述
研究领域：神经科学
[Gly14]-人源蛋白（HNG）属于线粒体衍生肽家族。HNG（人蛋白-G）是人源蛋白的类似物，由 S14G（丝氨酸-14-甘氨酸）突变产生。HNG 表现出 1000 倍的更强活性。
[Gly14]-人源蛋白（HNG）属于线粒体衍生肽家族。HNG（人蛋白-G）是人源蛋白的类似物，由 S14G（丝氨酸-14-甘氨酸）突变产生。HNG 表现出 1000 倍的更强活性。
应用
[Gly14]-人源蛋白 G 人已被用于：
- 与硼替佐米一起进行药理学抑制研究，以治疗小鼠，限制硼替佐米毒副作用
- 研究其对高糖（HG）诱导的内皮细胞（EC）凋亡的影响
- 利用 SH-SY5Y 神经母细胞瘤细胞在体外氧-糖剥夺/复氧（OGD/R）模型中研究其神经保护作用
在新生臂丛神经损伤（NBPI）小鼠模型中，硼替佐米治疗期间，[甘氨酸¹⁴]-人源蛋白 G 已被用于限制毒性。它还被用于人类来源的神经母细胞瘤细胞系的细胞培养。
生化/生理作用
[Gly14]-人源蛋白（HNG）刺激细胞生长、增殖和细胞周期进展。它增强激酶、转运蛋白、跨膜受体、转录和翻译调节因子等蛋白质。与天然 HN 相比，HNG 在体外表现出强烈的神经保护作用。研究表明，它在体外和体内都是一种有效的细胞保护剂。HNG 被发现可以防止高糖（HG）诱导的内皮细胞（EC）凋亡。它被证明可以抑制血管平滑肌细胞（VSMCs）中 AngII 诱导的表型转换。
内源性救援因子通过广泛的家族性阿尔茨海默病基因和aβ消除神经细胞死亡
抗体
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
Meng-Yuan Shen et al.
Diabetes, metabolic syndrome and obesity : targets and therapy, 14, 2335-2347 (2021-06-04)
Humanin, a newly emerging endogenously expressed cytoprotective peptide, has been shown to have anti-apoptotic properties effects by protecting neuronal cells injury. Endothelial microparticles (EMPs) are considered as vital mediators in intercellular communication. EMPs may regulate various physiological and pathological processes
Guangsheng Gao et al.
Neurological research, 39(10), 895-903 (2017-07-20)
Humanin (HN) has been identified to suppress neuron death. Gly Rats were randomly divided into 13 groups: Sham group, GI groups and HNG groups. Both GI group and HNG groups included six time points (1, 3, 6, 12, 24, and
Sia Nikolaou et al.
JCI insight, 4(23) (2019-10-30)
Muscle contractures are a prominent and disabling feature of many neuromuscular disorders, including the 2 most common forms of childhood neurologic dysfunction: neonatal brachial plexus injury (NBPI) and cerebral palsy. There are currently no treatment strategies to directly alter the
Qingnian Goh et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(2), e21214-e21214 (2020-11-26)
Neonatal brachial plexus injury (NBPI) causes disabling and incurable contractures, or limb stiffness, which result from proteasome-mediated protein degradation impairing the longitudinal growth of neonatally denervated muscles. We recently showed in a mouse model that the 20S proteasome inhibitor, bortezomib
Bo Su et al.
Aging, 15(14), 6822-6833 (2023-07-15)
Asthma is a chronic inflammatory disease with a high morbidity rate in children and significantly impacts their healthy growth. It is reported that Th2 cell-mediated airway inflammation and activated oxidative stress are involved in the pathogenesis of asthma. S14G-humanin (HNG)
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