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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to tan
溶解性
DMSO: soluble 20 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
CCCc1c(nn(-c2ccc(O)cc2)c1-c3ccc(O)cc3)-c4ccc(O)cc4
InChI
1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,27-29H,2-3H2,1H3
InChI key
IOTXSIGGFRQYKW-UHFFFAOYSA-N
基因信息
human ... ESR1(2099)
一般描述
雌激素受体 α(ERα）是核受体超家族成员。它也被称为 ESR1（雌激素受体）。它位于人类染色体 6q25.1。
1,3,5-三（4-羟基苯基）-4-丙基-1H-吡唑也称为 PPT。ERα在主神经元和抑制性神经元的核内和核外部位发现。
1,3,5-三（4-羟基苯基）-4-丙基-1H-吡唑也称为 PPT。ERα在主神经元和抑制性神经元的核内和核外部位发现。
应用
已使用 1,3,5-三（4-羟基苯基）-4-丙基-1H-吡唑培养分化的脂肪细胞。也用于药物治疗 和放射免疫测定 (RIA)。
生化/生理作用
雌激素受体 α(ERα）参与免疫和炎症反应。ESR1 的异常导致 Mayer-Rokitansky-Kuster-Hauser 综合征，该综合征与先天性子宫和阴道上 2/3 缺失相关。
PPT 是一种特异性雌激素受体 α(ERα)激动剂。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Tibolone protects astrocytic cells from glucose deprivation through a mechanism involving estrogen receptor beta and the upregulation of neuroglobin expression
Avila R M, et al.
Molecular and Cellular Endocrinology, 433(12), 35-46 (2016)
Estrogen receptor alpha and beta specific agonists regulate expression of synaptic proteins in rat hippocampus
Waters E M, et al.
Brain Research, 1290(11), 1-11 (2009)
Maryam Iravani et al.
The Journal of endocrinology, 232(3), 403-410 (2016-12-22)
Estrogens are well known for their capacity to promote bone maturation and at high doses to induce growth plate closure and thereby stop further growth. High-dose estrogen treatment has therefore been used to limit growth in extremely tall girls. However
Pituitary estrogen receptor alpha is involved in luteinizing hormone pulsatility at mid-gestation in the South American plains vizcacha, Lagostomus maximus (Rodentia, Caviomorpha)
Proietto S, et al.
General and Comparative Endocrinology, 433(12), 35-46 (2018)
Naohito Kitamura et al.
PloS one, 4(4), e5159-e5159 (2009-04-10)
The M(5) muscarinic acetylcholine receptor is known to play a crucial role in mediating acetylcholine dependent dilation of cerebral blood vessels. Previously, we reported that male M(5) muscarinic acetylcholine knockout mice (M5R(-/-) mice) suffer from a constitutive constriction of cerebral
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