产品名称
人类生长激素 人, HGH, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
biological source
human
recombinant
expressed in HEK 293 cells
assay
≥95% (SDS-PAGE)
form
lyophilized powder
potency
≤0.5 ng/mL EC50
mol wt
monomer 22 kDa (non-glycosylated)
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
<1 EU/mg
storage temp.
−20°C
Quality Level
Analysis Note
通过对大鼠淋巴瘤细胞系Nb2-11细胞（催乳素指示细胞系）的增殖进行剂量依赖性刺激来检测活性。
Application
人类生长激素已用作培养基补充物，研究人类生长激素对鱼细胞系免疫应答的影响。它也被用作胆道分化培养基(BDM)的补充物，用于分化人胚胎干细胞(hESCs)/人诱导多能干细胞(hiPSCs)衍生的肝母细胞。
Biochem/physiol Actions
人类生长激素(HGH)是人类正常生长发育所必需的物质。HGH通过刺激胰岛素样生长因子I的表达来改变多种生理功能，并可增加钙潴留和骨密度。生长激素增加肌肉量，促进脂肪分解，减少肝脏对葡萄糖的摄取。HGH调节异常导致各种生长障碍，如HGH分泌过多导致的巨人症或肢端肥大症。反之，生长激素缺乏导致儿童生长缺陷和成人生长激素缺乏综合征。
General description
人类生长激素(HGH)，也称为促生长激素，是一种由长单链氨基酸组成的肽激素。它由人体垂体前叶的促生长细胞自然分泌。
Physical form
从0.2 μm过滤的 1x PBS溶液中冻干。
Preparation Note
HumanKine，人生长激素（HGH），作为一种非糖基化单体表达于人HEK 293细胞中，表观分子量为22kDa。
Legal Information
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Wen-Jen Chung et al.
Protein expression and purification, 110, 79-88 (2015-02-24)
Growth hormone (GH) performs important roles in regulating somatic growth, reproduction, osmoregulation, metabolism and immunity in teleosts, and thus, it has attracted substantial attention in the field of aquaculture application. Herein, giant grouper GH (ggGH) cDNA was cloned into the
J P Pontigo et al.
General and comparative endocrinology, 300, 113631-113631 (2020-10-04)
To clarify the role of growth hormone (GH) in the immune system of fish, we examine the comparative effect of GH and Growth Hormone Release Factor (GRF) on leukocytes culture of the head kidney of Atlantic salmon and the SHK-1
Maximilian Bielohuby et al.
Disease models & mechanisms, 7(11), 1263-1273 (2014-09-23)
The development of new growth hormone (GH) agonists and growth hormone antagonists (GHAs) requires animal models for pre-clinical testing. Ideally, the effects of treatment are monitored using the same pharmacodynamic marker that is later used in clinical practice. However, intact
Maïté Verreault et al.
Clinical and translational medicine, 12(7), e939-e939 (2022-07-10)
New therapeutic approaches are needed to improve the prognosis of glioblastoma (GBM) patients. With the objective of identifying alternative oncogenic mechanisms to abnormally activated epidermal growth factor receptor (EGFR) signalling, one of the most common oncogenic mechanisms in GBM, we
Noushin Dianat et al.
Hepatology (Baltimore, Md.), 60(2), 700-714 (2014-04-10)
Cholangiocytes are biliary epithelial cells, which, like hepatocytes, originate from hepatoblasts during embryonic development. In this study we investigated the potential of human embryonic stem cells (hESCs) to differentiate into cholangiocytes and we report a new approach, which drives differentiation
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