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产品名称
人类生长激素 人, HGH, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
生物来源
human
质量水平
重组
expressed in HEK 293 cells
方案
≥95% (SDS-PAGE)
表单
lyophilized powder
效能
≤0.5 ng/mL EC50
分子量
monomer 22 kDa (non-glycosylated)
包装
pkg of 10 μg
储存条件
avoid repeated freeze/thaw cycles
技术
cell culture | mammalian: suitable
杂质
≤1 EU/mg
储存温度
−20°C
一般描述
人类生长激素(HGH)，也称为促生长激素，是一种由长单链氨基酸组成的肽激素。它由人体垂体前叶的促生长细胞自然分泌。
应用
人类生长激素已用作培养基补充物，研究人类生长激素对鱼细胞系免疫应答的影响。它也被用作胆道分化培养基(BDM)的补充物，用于分化人胚胎干细胞(hESCs)/人诱导多能干细胞(hiPSCs)衍生的肝母细胞。
生化/生理作用
人类生长激素(HGH)是人类正常生长发育所必需的物质。HGH通过刺激胰岛素样生长因子I的表达来改变多种生理功能，并可增加钙潴留和骨密度。生长激素增加肌肉量，促进脂肪分解，减少肝脏对葡萄糖的摄取。HGH调节异常导致各种生长障碍，如HGH分泌过多导致的巨人症或肢端肥大症。反之，生长激素缺乏导致儿童生长缺陷和成人生长激素缺乏综合征。
外形
从0.2 μm过滤的 1x PBS溶液中冻干。
制备说明
HumanKine，人生长激素（HGH），作为一种非糖基化单体表达于人HEK 293细胞中，表观分子量为22kDa。
分析说明
通过对大鼠淋巴瘤细胞系Nb2-11细胞（催乳素指示细胞系）的增殖进行剂量依赖性刺激来检测活性。
法律信息
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
J P Pontigo et al.
General and comparative endocrinology, 300, 113631-113631 (2020-10-04)
To clarify the role of growth hormone (GH) in the immune system of fish, we examine the comparative effect of GH and Growth Hormone Release Factor (GRF) on leukocytes culture of the head kidney of Atlantic salmon and the SHK-1
Wen-Jen Chung et al.
Protein expression and purification, 110, 79-88 (2015-02-24)
Growth hormone (GH) performs important roles in regulating somatic growth, reproduction, osmoregulation, metabolism and immunity in teleosts, and thus, it has attracted substantial attention in the field of aquaculture application. Herein, giant grouper GH (ggGH) cDNA was cloned into the
Maïté Verreault et al.
Clinical and translational medicine, 12(7), e939-e939 (2022-07-10)
New therapeutic approaches are needed to improve the prognosis of glioblastoma (GBM) patients. With the objective of identifying alternative oncogenic mechanisms to abnormally activated epidermal growth factor receptor (EGFR) signalling, one of the most common oncogenic mechanisms in GBM, we
Maximilian Bielohuby et al.
Disease models & mechanisms, 7(11), 1263-1273 (2014-09-23)
The development of new growth hormone (GH) agonists and growth hormone antagonists (GHAs) requires animal models for pre-clinical testing. Ideally, the effects of treatment are monitored using the same pharmacodynamic marker that is later used in clinical practice. However, intact
Noushin Dianat et al.
Hepatology (Baltimore, Md.), 60(2), 700-714 (2014-04-10)
Cholangiocytes are biliary epithelial cells, which, like hepatocytes, originate from hepatoblasts during embryonic development. In this study we investigated the potential of human embryonic stem cells (hESCs) to differentiate into cholangiocytes and we report a new approach, which drives differentiation
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