H5789
Anti-HuD antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-ELAVL4, Anti-Human Antigen D
产品名称
Anti-HuD antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 40 kDa
species reactivity
human, mouse
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 10-20 μg/mL using heat retrieved, human intestine tissue
western blot (chemiluminescent): 5-10 μg/mL using mouse brain extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ELAVL4(1996)
mouse ... Elavl4(15572)
Application
Anti-HuD antibody produced in rabbit may be used in immunoblotting and immunohistochemistry.
Biochem/physiol Actions
Anti-HuD specifically recognizes human and mouse HuD.
Hu antigen D (HuD) protein binds to the 3′ untranslated region (UTR) of mRNA of genes like N-myc gene and growth-associated protein (GAP43). This binding results in an increase in the half-life of these mRNA. HuD plays a vital role in several regulatory processes, such as the processing of pre-mRNA, mRNA stability and translation. This protein is also involved in neuronal functioning and development. HuD protein also plays a role in neuronal plasticity, which includes, learning and memory, recovery from axonal injury and multiple neurological diseases.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Hu antigen D (HuD) protein is highly conserved and a neuron-specific RNA-binding protein. This protein belongs to the embryonic lethal, abnormal vision, Drosophila-like (ELAVL)/Hu family. The HuD gene is located on the human chromosome at 1p33-p32.3.
HuD protein binds to the 3′ UTR of mRNA of geneslike N-myc gene and GAP43, and increases the half-life ofthese mRNA.
Immunogen
synthetic peptide corresponding to amino acids 240-255 of human HuD with an N-terminal added cysteine, conjugated to KLH.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide and 1% inactivated bovine serum albumin.
Preparation Note
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
The Chromosomal Aberrations in the Head and Neck Squamous Cell Carcinoma Cell Lines: PCI-1, PCI-13 and PCI-50
Moon Y E, et al.
Korean Journal of Otorhinolaryngology - Head and Neck Surgery, 52(9), 741-750 (2009)
Lucas M Bronicki et al.
RNA (New York, N.Y.), 19(8), 1019-1037 (2013-07-19)
Precise control of messenger RNA (mRNA) processing and abundance are increasingly being recognized as critical for proper spatiotemporal gene expression, particularly in neurons. These regulatory events are governed by a large number of trans-acting factors found in neurons, most notably
Feifei Wang et al.
Anticancer research, 37(8), 4515-4522 (2017-07-26)
The ELAVL4 (HuD) is a neuron-specific RNA-binding protein expressed in 100% of small cell lung cancer (SCLC) cells and over 50% of neuroblastoma cells. The aim of this study was to investigate the serum HuD concentration in SCLC patients and
Riccardo De Santis et al.
Cell reports, 27(13), 3818-3831 (2019-06-27)
Amyotrophic lateral sclerosis (ALS) has been genetically linked to mutations in RNA-binding proteins (RBPs), including FUS. Here, we report the RNA interactome of wild-type and mutant FUS in human motor neurons (MNs). This analysis identified a number of RNA targets.
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