推荐产品
应用
组蛋白适用于：
- 作为体外激酶测定的阳性对照，检测Cdc2-细胞周期蛋白B1磷酸化GST-CD-4蛋白的能力
- Cdk5活性测定
- 组蛋白H1激酶测定
- 作为聚ADP-核糖(PAR)受体，检测体外PAR聚合酶活性
- 作为[γ-32P]ATP来源32P的受体，检测小、大黄体细胞来源裂解液的蛋白激酶活性
生化/生理作用
组蛋白是一组DNA结合蛋白，其特征是赖氨酸和精氨酸含量较高。组蛋白的分子量在11-21 kDa之间，取决于具体级分。分离和表征了五种不同的组蛋白级分。H1富含赖氨酸、H2a和H2b略微富含赖氨酸、H3和H4富含精氨酸。H1用于连接染色质链上的各个“念珠”(nu bodies)。
特点和优势
不要将Sigma“类型”名称与Luck及其同事使用的“分级”名称混淆。
其他说明
经SDS-PAGE鉴定，主要为f1亚型
制备说明
富含赖氨酸的级分，分离和描述依据文献（de Nooij, E. and Westenbrink, H.G., BiochimBiophys.Acta, 62, 608 (1962)）。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Scott T
Concise encyclopedia of biochemistry, 265-265 (1988)
Liang Zheng et al.
Haematologica, 105(4), 1107-1119 (2019-11-23)
Thrombotic thrombocytopenic purpura (TTP) is caused by severe deficiency of ADAMTS13 (A13), a plasma metalloprotease that cleaves endothelium-derived von Willebrand factor (VWF). However, severe A13 deficiency alone is often not sufficient to cause an acute TTP; additional factors may be
Q P Dou et al.
Cancer research, 53(7), 1493-1497 (1993-04-01)
Progression of cells into S phase is proposed to be determined by accumulation of a labile protein (the restriction point protein R; A. B. Pardee, Proc. Natl. Acad. Sci. USA, 71: 1286-1290, 1974). We report here that cyclin E and
Anne Cecília Nascimento da Cruz et al.
Pharmaceuticals (Basel, Switzerland), 12(4) (2019-11-21)
Fourteen arylsemicarbazone derivatives were synthesized and evaluated in order to find agents with potential anticancer activity. Cytotoxic screening was performed against K562, HL-60, MOLT-4, HEp-2, NCI-H292, HT-29 and MCF-7 tumor cell lines. Compounds 3c and 4a were active against the
Mária Čížková et al.
Cells, 8(7) (2019-07-20)
DNA damage is a ubiquitous threat endangering DNA integrity in all living organisms. Responses to DNA damage include, among others, induction of DNA repair and blocking of cell cycle progression in order to prevent transmission of damaged DNA to daughter
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