生物来源
human
质量水平
重组
expressed in E. coli
描述
purified, soluble
检测方案
3.5—25 mg protein/mL (Bradford)
形式
liquid
比活
12-200 units/mg protein
分子量
57318.7 g/mol
浓度
3.5-25 mg protein/mL (protein)
50-150 nmol/mL (P450)
6-14 nmol/mg protein (specific content)
技术
cell based assay: suitable
溶解性
water: soluble
NCBI登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... CYP3A4(1576)
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一般描述
Research area: IMMUNO AND CKS
Cytochrome P450 3A4 (CYP3A4) indicates a mammalian enzyme (CYP) family 3, subfamily A, gene 4. There are 57 CYP genes and 33 pseudogenes in humans, organized into 18 families and 42 subfamilies. Among these, the 3A4 isoform (CYP3A4) is the most prevalent and is primarily found in the liver and gastrointestinal tract.
Cytochrome P450 3A4 (CYP3A4) indicates a mammalian enzyme (CYP) family 3, subfamily A, gene 4. There are 57 CYP genes and 33 pseudogenes in humans, organized into 18 families and 42 subfamilies. Among these, the 3A4 isoform (CYP3A4) is the most prevalent and is primarily found in the liver and gastrointestinal tract.
应用
细胞色素 P450 3A4 人类已用于圆二色性分析。
生化/生理作用
细胞色素 P450 3A4（CYP3A4）是细胞色素 P450（P450s）的同工型之一。细胞色素 P450（P450）在加工内源性化合物和生物异源物质（包括污染物、环境化合物和药物分子）中起到关键作用。CYP3A4 通过各种代谢过程氧化超过 90％ 的已上市药物。
单位定义
在 37°C，pH 7.4 条件下，一个单位每分钟将 1.0 纳摩尔的睾丸酮转化为 6-β-睾丸酮。
其他说明
Supplied as purified soluble proteins, rather than microsomal preparations.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
Understanding the mechanism of cytochrome P450 3A4: recent advances and remaining problems
Sevrioukova IF, et al.
Journal of Separation Science, 42(9), 3116-3126 (2013)
Understanding the mechanism of cytochrome P450 3A4: recent advances and remaining problems
Sevrioukova IF, et al.
Journal of Separation Science, 42(9), 3116-3126 (2013)
Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver
Zhang Y, et al.
Advances in Functional Materials, 26(6), 841-850 (2016)
Elisavet Stavropoulou et al.
Frontiers in immunology, 9, 89-89 (2018-02-16)
Cytochromes are expressed in many different tissues of the human body. They are found mostly in intestinal and hepatic tissues. Cytochromes P450 (CYPs) are enzymes that oxidize substances using iron and are able to metabolize a large variety of xenobiotic
Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition
Dresser, et al.
Clinical Pharmacokinetics, 38(1), 41-57 (2000)
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