product name
HMG-1 人, lyophilized powder, ≥90% (SDS-PAGE), Histidine-tagged, recombinant, expressed in E. coli
重组
expressed in E. coli
质量水平
检测方案
≥90% (SDS-PAGE)
形式
lyophilized powder
分子量
25 kDa
UniProt登记号
运输
dry ice
储存温度
−20°C
SMILES字符串
COC(=O)CCCCCCCCCCCCCCO
基因信息
human ... HMGB1(3146)
一般描述
HMG-1（高迁移率族蛋白）是分子量为30kDa的核蛋白。它由巨噬细胞、单核细胞和坏死细胞分泌。它广泛表达。该蛋白质具有碱性 HMG（高迁移率族）盒结构域和酸性羧基末端。
215 amino acids; comprises two homologous HMG boxes, rich in basic amino acids, and an acidic tail at the carboxy-terminus
应用
HMG-1（高迁移率族蛋白）人已用于：
- 使用ELISA（酶联免疫吸附测定）测试，制备用于测量 HMG1的标准曲线
- 研究在外源 HMG-1 存在下 Lewis细胞的凋亡比例
- 研究在体外条件下，HMG-1 存在时，Th（T辅助细胞）-17细胞扩增的变化
- 用于GM7373细胞的迁移测定
生化/生理作用
HMG-1（高迁移率族蛋白）是非组蛋白染色体蛋白，其促进蛋白质序列特异性 DNA 附着。HMG1以非序列特异性方式结合 DNA。它参与DNA 复制、转录和修复。此外，它在癌症中上调并且与细胞生长、血管发生和细胞凋亡调节有关。在感染或损伤的情况下，HMG1 被分泌并介导炎症。它与自身免疫疾疾病的发病机制有关，例如类风湿性关节炎（RA）、炎性肠病（IBD）和系统性红斑狼疮（SLE）。
外形
含有HEPES 缓冲盐，pH 7.8，NaCl，EDTA，Triton X-100，亮抑酶肽和AEBSF的冻干粉。
分析说明
DNA 延迟测定试验
警示用语：
Danger
危险声明
危险分类
Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
常规特殊物品
Tian-Tian Ma et al.
PloS one, 10(4), e0123586-e0123586 (2015-04-18)
High mobility group box-1 (HMGB1), a kind of pro-inflammatory mediator, is associated with inflammatory conditions and tissue damage. Our previous study demonstrated that the circulating levels of HMGB1 correlated with disease activity of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). In
X Xu et al.
Scandinavian journal of immunology, 79(6), 386-394 (2014-03-29)
Upregulated high-mobility group box 1 (HMGB1) has been found in many diseases. Nevertheless, the function of HMGB1 on modulating the proliferation of lung cancer cells (Lewis cells) and inhibiting apoptosis is poorly understood, as well as the involved intracellular signalling.
A Taguchi et al.
Nature, 405(6784), 354-360 (2000-06-01)
The receptor for advanced glycation end products (RAGE), a multi-ligand member of the immunoglobulin superfamily of cell surface molecules, interacts with distinct molecules implicated in homeostasis, development and inflammation, and certain diseases such as diabetes and Alzheimer's disease. Engagement of
Julia Matena et al.
International journal of molecular sciences, 16(4), 7478-7492 (2015-04-08)
To improve well-known titanium implants, pores can be used for increasing bone formation and close bone-implant interface. Selective Laser Melting (SLM) enables the production of any geometry and was used for implant production with 250-µm pore size. The used pore
H Wang et al.
Science (New York, N.Y.), 285(5425), 248-251 (1999-07-10)
Endotoxin, a constituent of Gram-negative bacteria, stimulates macrophages to release large quantities of tumor necrosis factor (TNF) and interleukin-1 (IL-1), which can precipitate tissue injury and lethal shock (endotoxemia). Antagonists of TNF and IL-1 have shown limited efficacy in clinical
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