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文件

安全信息

H4516

Sigma-Aldrich

Hydrocodone (+)-bitartrate salt

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别名:
4,5-Epoxy-3-methoxy-17-methyl-5α-morphinan-6-one (2R,3R)-2,3-dihydroxybutanedioate (1:1)
经验公式（希尔记法）:
C18H21NO3 · C4H6O6
CAS号:
143-71-5
分子量:
449.45
EC 号:
205-608-1
MDL编号:
MFCD00078557
UNSPSC代码:
12352200
PubChem化学物质编号:
24895519
NACRES:
NA.77

质量水平

200

药品控制

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

技术

HPLC: suitable
gas chromatography (GC): suitable

溶解性

H2O: 62 mg/mL
ethanol: soluble

应用

forensics and toxicology
veterinary

创始人

Abbott

SMILES字符串

O[C@H]([C@@H](O)C(O)=O)C(O)=O.[H][C@]12CCC(=O)[C@]3([H])Oc4c(OC)ccc5C[C@H]1N(C)CC[C@@]23c45

InChI

1S/C18H21NO3.C4H6O6/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;5-1(3(7)8)2(6)4(9)10/h3,6,11-12,17H,4-5,7-9H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/t11-,12+,17-,18-;1-,2-/m01/s1

InChI key

OJHZNMVJJKMFGX-BWCYBWMMSA-N

相关类别

生化/生理作用

μ opioid receptor agonist; narcotic analgesic and antitussive.

特点和优势

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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C J Kotzer et al.
The Journal of pharmacology and experimental therapeutics, 292(2), 803-809 (2000-01-20)
In this study, the activity of the delta-opioid receptor subtype-selective agonist, SB 227122, was investigated in a guinea pig model of citric acid-induced cough. Parenteral administration of selective agonists of the delta-opioid receptor (SB 227122), mu-opioid receptor (codeine and hydrocodone)
Z R Chen et al.
Life sciences, 48(22), 2165-2171 (1991-01-01)
The binding affinity to the mu receptor of some opioids chemically related to morphine and some of their metabolites was examined in rat brain homogenates with 3H-DAMGO. The chemical group at position 6 of the molecule had little effect on
D M Tomkins et al.
The Journal of pharmacology and experimental therapeutics, 280(3), 1374-1382 (1997-03-01)
Humans that lack cytochrome P450 2D6 (CYP2D6) activity may have an altered risk of drug dependence or abuse because this enzyme is important in the metabolism of some drugs of abuse, including hydrocodone. In rats, hydrocodone conversion to hydromorphone is

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