产品名称
猪去氧胆酸, ≥98%
质量水平
方案
≥98%
mp
200-201 °C (lit.)
SMILES字符串
C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI
1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1
InChI key
DGABKXLVXPYZII-SIBKNCMHSA-N
基因信息
human ... NR1H2(7376), NR1H3(10062)
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相关类别
一般描述
异去氧胆酸是天然存在的次级胆汁酸。它通过小肠中的肠道菌群产生。在大鼠中，异去氧胆酸在胆汁的肠肝循环过程中由鹅去氧胆酸获得。
应用
异去氧胆酸已被用于：
- 作为液相色谱-质谱（LC-MS）联用法分析大鼠细胞中血清胆汁酸的标准品。
- 作为生长培养基的成分用于研究其作为抗衰老小分子对pex5Δ (Δ) 菌株时序寿命 (CLS) 的影响。
- 作为分析小鼠细胞中胆汁酸组成和总胆汁酸的成分。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Hang Zeng et al.
British journal of pharmacology, 174(8), 672-688 (2017-01-28)
Currently, ursodeoxycholic acid and obeticholic acid are the only two FDA-approved drugs for cholestatic liver diseases. Thus, new therapeutic approaches need to be developed. Here we have evaluated the anti-cholestasis effects of Schisandrol B (SolB), a bioactive compound isolated from
Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition
Cepa S, et al.
Toxicology and Applied Pharmacology, 338(9), 204-213 (2018)
Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes
Goldberg A A, et al.
Aging (Albany. NY.), 2(7), 393-393 (2010)
Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice.
Joseph F Pierre et al.
American journal of physiology. Gastrointestinal and liver physiology, 311(2), G286-G304 (2016-06-25)
The metabolic benefits induced by gastric bypass, currently the most effective treatment for morbid obesity, are associated with bile acid (BA) delivery to the distal intestine. However, mechanistic insights into BA signaling in the mediation of metabolic benefits remain an
Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice
Pierre J F, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 311(2), G286-G304 (2016)
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