H3524
单克隆抗-热休克蛋白 60 小鼠抗
clone LK2, ascites fluid
别名:
Anti-CPN60, Anti-GROEL, Anti-HLD4, Anti-HSP-60, Anti-HSP60, Anti-HSP65, Anti-HuCHA60, Anti-SPG13
产品名称
单克隆抗-热休克蛋白 60 小鼠抗, clone LK2, ascites fluid
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
LK2, monoclonal
mol wt
antigen 60 kDa
contains
15 mM sodium azide
species reactivity
spinach, chicken, E. coli, helminth, rat, human
technique(s)
electron microscopy: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: 1:100 using cultured human foreskin fibroblast extract
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HSPD1(3329)
rat ... Hspd1(63868)
Application
小鼠抗热休克蛋白60单克隆抗体可用于：蛋白质印迹，免疫细胞化学，酶联免疫吸附测定（ELISA），免疫印迹
Biochem/physiol Actions
各种环境破坏（例如温度突然升高）会诱导细胞迅速合成一组多肽，这些多肽被称为热休克（应激）蛋白。 60 kDa HSP家族（HSP60）在进化过程中保留了独特的高水平的序列保守性，是许多自身免疫性疾病中潜在抗原的关注焦点。 涉及HSP60的异常免疫反应性也与精神分裂症的发病机理有关。 在人类关节炎和动物实验诱导的关节炎中，疾病的发展与不仅针对细菌HSP60，而且针对其哺乳动物同源物的免疫反应性的发展相吻合。 最初称为P1的人类线粒体蛋白已被描述为细菌HSP60的人类同源物，并且>45%的蛋白与其细菌同源物（groEL，HSP65）具有序列同一性。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
单克隆抗热休克蛋白60（HSP60），克隆LK2，可识别位于人HSP60的氨基酸残基383-419（对应于分枝杆菌的氨基酸残基356-393）之间的表位。 该抗体对哺乳动物（例如人、大鼠）、禽类（例如鸡）、细菌（例如大肠埃希菌）、蠕虫和菠菜HSP60具有反应性。 在免疫印迹中，抗体可标记约38和97 kDa处的额外条带。 它与组成型和诱导型HSP60都反应。 它显示了取自青少年慢性关节炎患者的福尔马林固定，石蜡包埋的滑膜的免疫组化染色水平升高。
单克隆抗热休克蛋白60（小鼠IgG1亚型）分离自LK2杂交瘤，其通过融合小鼠骨髓瘤细胞和来自用从租人热休克蛋白60免疫的BALB/c小鼠的脾细胞产生。
Immunogen
重组人热休克蛋白60（HSP60）。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
常规特殊物品
此项目有
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