H3166
Anti-HOXD4 (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-HHO.C13, Anti-HOX-4B, Anti-HOX-5.1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IP, WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~35 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 1.5-3 μg using lysates of HEK-293T cells over-expressing human HOXD4, indirect immunofluorescence: 0.25-0.5 μg/mL using paraformaldehyde fixed HEK-293T cells over expressing human HOXD4, western blot: 0.5-1 μg/mL using lysates of HEK-293T cells over-expressing human HOXD4
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HOXD4(3233)
rat ... Hoxd4(288153)
General description
The Homeobox D4 (HOXD4) gene is expressed in mesodermal tissues and the central nervous system (CNS). The HOXD4 gene is mapped on the human chromosome at 2q31.1.
Application
Anti-HOXD4 (C-terminal) antibody produced in rabbit may be used in:
- immunoblotting
- immunoprecipitation
- immunofluorescence
Biochem/physiol Actions
Anti-HOXD4 (C-terminal) recognizes human HOXD4 (also known as HOX-4B, HOX-5).
The Homeobox D4 (HOXD4) gene is involved in the development of dura mater and morphogenesis of the development of the spine. This gene plays a role in the pathogenesis of spinal extradural arachnoid cyst (SEDAC). HOXD4 gene is also involved in tumorigenesis of the central nervous system. This gene acts as a diagnostic marker of gliomas.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Hui Liu et al.
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association, 25(1), 46-54 (2018-12-28)
Homeobox D4 (HOXD4) belongs to the homeobox (HOX) family, which plays a crucial role in the early embryo development and cell differentiation. The role of HOXD4 in human gastric adenocarcinoma has not been elucidated. In the present study, we aimed
Xin-Wei Zhao et al.
Oncotarget, 8(70), 115657-115666 (2018-02-01)
HOX (homologous box) is known as the dominant gene of vertebrate growth and cell differentiation. Abnormal expression of HOX gene in various tumors has attracted the attention of scholars. As a component of HOX clusters, HOXD4 plays a controversial role
Yoji Ogura et al.
PloS one, 10(11), e0142126-e0142126 (2015-11-07)
Spinal extradural arachnoid cyst (SEDAC) is a cyst in the spinal canal that protrudes into the epidural space from a defect in the dura mater and leads to neurological disturbances. We previously showed that familial SEDAC is caused by FOXC2
Mojgan Rastegar et al.
Molecular and cellular biology, 24(18), 8090-8103 (2004-09-02)
Hox genes are differentially expressed along the embryonic anteroposterior axis. We used chromatin immunoprecipitation to detect chromatin changes at the Hoxd4 locus during neurogenesis in P19 cells and embryonic day 8.0 (E8.0) and E10.5 mouse embryos. During Hoxd4 induction in
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