推荐产品
产品名称
20-羟基-（5Z,8Z,11Z,14Z）-二十碳四烯酸, ~100 μg/mL in ethanol, ≥90% (HPLC)
质量水平
方案
≥90% (HPLC)
表单
liquid
浓度
~100 μg/mL in ethanol
运输
dry ice
储存温度
−20°C
SMILES字符串
OCCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
InChI
1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10-
InChI key
NNDIXBJHNLFJJP-DTLRTWKJSA-N
生化/生理作用
20-羟基-（5Z，8Z，11Z，14Z）-二十碳四烯酸（20-HETE）是通过细胞色素P4504A的花生四烯酸代谢产物，它是Ras/MAP（微管相关蛋白）途径的激活剂。20-HETE酸是肾脏中主要的花生四烯酸。 它参与调节肾小管的钠、钾和氯化物转运。20-HETE通常以葡糖醛酸结合物的形式排泄在尿液中，有时以游离酸的形式排泄。在大鼠妊娠期间观察到尿液20-HETE增加。
包装
在氩气下包装。
警示用语：
Danger
危险声明
危险分类
Eye Irrit. 2 - Flam. Liq. 2
储存分类代码
3 - Flammable liquids
WGK
WGK 1
闪点(°F)
57.2 °F - closed cup
闪点(°C)
14.0 °C - closed cup
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
危险化学品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Tiago J Costa et al.
Frontiers in physiology, 9, 490-490 (2018-06-06)
Postmenopausal period has been associated to different symptoms such as hot flashes, vulvovaginal atrophy, hypoactive sexual desire disorder (HSDD) and others. Clinical studies have described postmenopausal women presenting HSDD can benefit from the association of testosterone to conventional hormonal therapy.
Elevated 12-and 20-hydroxyeicosatetraenoic acid in urine of patients with prostatic diseases
Nithipatikom K, et al.
Cancer Letters, 233(2), 219-225 (2006)
Anne Barden et al.
Free radical biology & medicine, 42(11), 1730-1735 (2007-04-28)
There is considerable evidence that chronic moderate-to-high alcohol consumption increases blood pressure. The mechanisms by which this occurs are not clear. Alcohol consumption can induce oxidative stress and cytochrome P450 (CYP450) isoforms that are associated with oxidative stress and may
Jonas C Fordsmann et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(6), 2562-2570 (2013-02-09)
Cortical spreading depression (CSD) is associated with release of arachidonic acid, impaired neurovascular coupling, and reduced cerebral blood flow (CBF), caused by cortical vasoconstriction. We tested the hypothesis that the released arachidonic acid is metabolized by the cytochrome P450 enzyme
K G Maier et al.
Current opinion in nephrology and hypertension, 10(1), 81-87 (2001-02-24)
Recent studies indicate that arachidonic acid is primarily metabolized by cytochrome P450 enzymes of the 4A and 2C families in the kidney to 20-hydroxyeicosatetraenoic acid (HETE), epoxyeicosatrienoic acids (EETs) and dihydroxyeicosatrienoic acids. These compounds play central roles in the regulation
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