H3023
20-羟基-（5Z,8Z,11Z,14Z）-二十碳四烯酸
≥90% (HPLC), liquid, Ras/MAP pathway activitor
别名:
20-HETE, 20-羟基花生四烯酸
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关于此项目
经验公式（希尔记法）:
C20H32O3
化学文摘社编号:
分子量:
320.47
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
20-羟基-（5Z,8Z,11Z,14Z）-二十碳四烯酸, ~100 μg/mL in ethanol, ≥90% (HPLC)
SMILES string
OCCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
InChI
1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10-
InChI key
NNDIXBJHNLFJJP-DTLRTWKJSA-N
assay
≥90% (HPLC)
form
liquid
concentration
~100 μg/mL in ethanol
shipped in
dry ice
storage temp.
−20°C
Quality Level
相关类别
Biochem/physiol Actions
20-羟基-（5Z，8Z，11Z，14Z）-二十碳四烯酸（20-HETE）是通过细胞色素P4504A的花生四烯酸代谢产物，它是Ras/MAP（微管相关蛋白）途径的激活剂。20-HETE酸是肾脏中主要的花生四烯酸。 它参与调节肾小管的钠、钾和氯化物转运。20-HETE通常以葡糖醛酸结合物的形式排泄在尿液中，有时以游离酸的形式排泄。在大鼠妊娠期间观察到尿液20-HETE增加。
Packaging
在氩气下包装。
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2
存储类别
3 - Flammable liquids
wgk
WGK 1
flash_point_f
57.2 °F - closed cup
flash_point_c
14.0 °C - closed cup
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
危险化学品
此项目有
Lingling Lu et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 39(3), 481-496 (2017-10-27)
Astrocytes express neurotransmitter receptors that serve as sensors of synaptic activity and initiate signals leading to activity-dependent local vasodilation and increases in blood flow. We previously showed that arteriolar vasodilation produced by activation of cortical astrocytes is dependent on endothelial
K G Maier et al.
Current opinion in nephrology and hypertension, 10(1), 81-87 (2001-02-24)
Recent studies indicate that arachidonic acid is primarily metabolized by cytochrome P450 enzymes of the 4A and 2C families in the kidney to 20-hydroxyeicosatetraenoic acid (HETE), epoxyeicosatrienoic acids (EETs) and dihydroxyeicosatrienoic acids. These compounds play central roles in the regulation
Jonas C Fordsmann et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(6), 2562-2570 (2013-02-09)
Cortical spreading depression (CSD) is associated with release of arachidonic acid, impaired neurovascular coupling, and reduced cerebral blood flow (CBF), caused by cortical vasoconstriction. We tested the hypothesis that the released arachidonic acid is metabolized by the cytochrome P450 enzyme
Anne Barden et al.
Free radical biology & medicine, 42(11), 1730-1735 (2007-04-28)
There is considerable evidence that chronic moderate-to-high alcohol consumption increases blood pressure. The mechanisms by which this occurs are not clear. Alcohol consumption can induce oxidative stress and cytochrome P450 (CYP450) isoforms that are associated with oxidative stress and may
Elevated 12-and 20-hydroxyeicosatetraenoic acid in urine of patients with prostatic diseases
Nithipatikom K, et al.
Cancer Letters, 233(2), 219-225 (2006)
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