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重组
expressed in E. coli
表单
buffered aqueous glycerol solution
比活
3-4 units/mL
分子量
104.1 kDa
浓度
1 mg/mL
相关疾病
cancer
运输
wet ice
储存温度
−20°C
一般描述
Hexokinase 2 is the predominant form found in skeletal muscle.
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Hexokinase 2 is the predominant form found in skeletal muscle.
应用
Hexokinase 2 (HK2) is a glycolytic enzyme that is crucial for the Warburg effect, which is the increased rate of glycolysis seen in rapidly growing cancer cells. HK2 may be used in cancer research to study human glioblastoma multiforme (GBM), which is the most common malignant brain tumor . HK2 may be a potential therapeutic target for breast cancer as HK2 overexpression is associated with metastasis to the brain .
生化/生理作用
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Hexokinase 2 is involved in glucose metabolism and apoptosis .
单位定义
One unit will produce 1.0 μmole NADPH per minute as glucose is phosphorylated by ATP at pH 7.4 at 30 deg C.
外形
Supplied in a solution containing 20 mM Tris pH 8.0 and 10% glycerol.
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Diane Palmieri et al.
Molecular cancer research : MCR, 7(9), 1438-1445 (2009-09-03)
Brain metastases of breast cancer seem to be increasingin incidence as systemic therapy improves. Metastatic disease in the brain is associated with high morbidity and mortality. We present the first gene expression analysis of laser-captured epithelial cells from resected human
Amparo Wolf et al.
The Journal of experimental medicine, 208(2), 313-326 (2011-01-19)
Proliferating embryonic and cancer cells preferentially use aerobic glycolysis to support growth, a metabolic alteration commonly referred to as the "Warburg effect." Here, we show that the glycolytic enzyme hexokinase 2 (HK2) is crucial for the Warburg effect in human
Helen S Bateup et al.
Neuron, 78(3), 510-522 (2013-05-15)
Neural circuits are regulated by activity-dependent feedback systems that tightly control network excitability and which are thought to be crucial for proper brain development. Defects in the ability to establish and maintain network homeostasis may be central to the pathogenesis
I Ray-Coquard et al.
British journal of cancer, 108(9), 1771-1777 (2013-04-25)
Patients with recurrent/metastatic endometrial cancer that progresses after chemotherapy have limited treatment options and poor outcomes. Preclinical data suggest the oral mammalian target of rapamycin inhibitor everolimus may provide clinical benefit in these patients. In this multicenter, open-label, phase 2
Venus Thomanetz et al.
The Journal of cell biology, 201(2), 293-308 (2013-04-10)
The mammalian target of rapamycin (mTOR) assembles into two distinct multi-protein complexes called mTORC1 and mTORC2. Whereas mTORC1 is known to regulate cell and organismal growth, the role of mTORC2 is less understood. We describe two mouse lines that are
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