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Merck
CN
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主要文件

H2779

Sigma-Aldrich

HistoChoice ® 透明剂

greener alternative

alternative to toluene and xylene

别名:

石蜡组织切片脱蜡复合液

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About This Item

UNSPSC代码:
12171500
NACRES:
NA.47

质量水平

100

表单

liquid

环保替代产品特性

Designing Safer Chemicals
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

颜色

colorless

密度

0.760-0.820 g/mL

应用

hematology
histology

环保替代产品分类

, Aligned

储存温度

room temp

相关类别

一般描述

HistoChoice®是一种专利所有的复合制剂，可使组织保留其结构、抗原位点和核酸位点。 它是特别配制的无毒、非交联固定剂，用于取代基于甲醛的固定剂。该制剂无柑橘味，不含汞、甲醛或戊二醛。

我们竭诚为您带来符合一项或多项绿色化学12项原则要求的绿色替代产品。相对于使用福尔马林进行组织处理的标准方法，本产品符合“本质安全化学物质”原则。

应用

HistoChoice®透明剂用途：
  • 适合作为甲苯和二甲苯的替代物用于石蜡组织切片脱蜡。制备的玻片适用于抗体探测和原位杂交。
  • 用于木质纤维素植物细胞壁抵抗酶解的抗降解屏障研究。
  • 用于建立新方法，提高对植物中miRNA及其目标转录本的定位灵敏度。
  • 研究癌症患者中细胞质ADP-核糖基化水平和临床结局标志物的关系。

生化/生理作用

HistoChoice®在免疫组织学分析中有良好的固定作用，它的非交联特性有利于抗原表位修复及胞外基质组分的一抗鉴定。

特点和优势

  • 无毒、 无致癌性、 无味。
  • 非易燃品。
  • 保留天然的抗原和核酸位点。
  • 兼容很多有机封片 剂。
  • 相比二甲苯，溶解蜡质更快，蒸发更慢。
  • 适用自动处理机器。
  • 组织保留原有结构。

法律信息

HistoChoice is a registered trademark of Amresco, Inc.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

142.0 °F

闪点(°C)

61.1 °C

个人防护装备

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCX2434
MKCX2433
MKCW5390
MKCW5391
MKCW5392

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Is HistoChoice Clearing Agent, product H2779, compatible with polycarbonate?

    The supplier of HistoChoice Clearing Agent has reported no incompatibilities were observed when polycarbonate was exposed to HistoChoice Clearning Agent for at least 1 hour.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Sathyanesan Samuel Newton et al.
Brain research. Brain research protocols, 9(3), 214-219 (2002-07-13)
A method is described to perform combined immunohistochemistry and in situ hybridization in mouse brain sections. The protocol is specific to sections mounted on glass slides. In contrast to earlier methods that require either paraffin embedding or perfusion of the
Synchrotron Time-Lapse Imaging of Lignocellulosic Biomass Hydrolysis: Tracking Enzyme Localization by Protein Autofluorescence and Biochemical Modification of Cell Walls by Microfluidic Infrared Microspectroscopy
Devaux, et al.
Frontiers in Plant Science (2018)
Cytoplasmic ADP-ribosylation levels correlate with markers of patient outcome in distinct human cancers
Aimi, et al.
Modern Pathology (2021)
Marie-Françoise Devaux et al.
Frontiers in plant science, 9, 200-200 (2018-03-09)
Tracking enzyme localization and following the local biochemical modification of the substrate should help explain the recalcitrance of lignocellulosic plant cell walls to enzymatic degradation. Time-lapse studies using conventional imaging require enzyme labeling and following the biochemical modifications of biopolymers
Anita S Patel et al.
The Journal of investigative dermatology, 128(12), 2888-2893 (2008-06-13)
An increasing number of studies report that genus beta human papillomaviruses (HPVs) are associated with skin cancer, with suggestions of specificity for squamous cell carcinoma (SCC) of the skin. We have conducted a systematic examination of HPV DNA in tumors
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