biological source
human
recombinant
expressed in E. coli
form
liquid
concentration
1 mg/mL
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Quality Level
Gene Information
human ... H4C1(121504)
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Application
Histone H4 human has been used in far-western blot analysis for protein identification. It has also been used in the preparation of standard protein solution for protein digestion.
Biochem/physiol Actions
Histones regulate transcription, DNA replication, DNA repair, and recombination.
General description
Histones are highly basic chromatin proteins. They tightly pack and organize eukaryotic DNA into nucleosomes. Nucleosomes consist of a histone octamer made of a tetramer of histones H3 and H4 with two dimers of histones H2A and H2B, wherein the 147 DNA base pairs are wrapped around this histone complex.
Other Notes
Supplied as 1 mg/mL in 20 mM NaPO4, pH 7.0, 0.3 M NaCl, 1 mM EDTA
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Shi Zheng et al.
Proteomics, 16(7), 1059-1068 (2016-02-04)
Concentrated formic acid is among the most effective solvents for protein solubilization. Unfortunately, this acid also presents a risk of inducing chemical modifications thereby limiting its use in proteomics. Previous reports have supported the esterification of serine and threonine residues
Khoa N Pham et al.
The journal of physical chemistry. B, 125(19), 4977-4986 (2021-05-12)
Histones are highly basic chromatin proteins that tightly package and order eukaryotic DNA into nucleosomes. While the atomic structure of the nucleosomes has been determined, the three-dimensional structure of DNA-free histones remains unresolved. Here, we combine tandem nonlinear and linear
Apurva Bhardwaj et al.
International journal of molecular sciences, 22(1) (2021-01-07)
Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) is an essential protein that regulates cellular processes such as cell proliferation, apoptosis, and differentiation. It is known to bind with several proteins to carry out various cellular functions. In this study, we
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